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Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder — PTSD  

Post-Traumatic Stress Disorder Clinical Trial

Official title:
Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder (PTSD)

Clinical Trial Summary

The primary purpose of this study is to investigate the efficacy of neurofeedback (NF) of real-time functional magnetic resonance imaging (rt-fMRI) data of the amygdala with regards to the reduction of post-traumatic stress disorder (PTSD) symptoms. A secondary purpose of this study is to use fMRI as a method of investigating brain function in individuals with PTSD. This study approach provides a tool for probing the neurobiology of PTSD by (1) testing the critical role of the amygdala in this disorder, and by (2) examining how amygdala connectivity is related to both amygdala regulation and clinical symptoms.

Clinical Trial Description

In pursuit of the overarching goals of this study, the investigators aim to: - determine if an experimental feedback intervention increases control over the region of interest (the amygdala) more than a control feedback intervention in which participants receive feedback that is unassociated with their PTSD symptoms. - determine if an experimental feedback intervention results in clinical improvements in PTSD symptoms relative to a control feedback intervention, and examine whether these improvements correlate with improved control over the amygdala. - determine if an experimental feedback intervention results in changes in resting state connectivity to the amygdala, and whether these changes correlate with symptom improvement and an improved ability to regulate the amygdala. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03574974
Study type Interventional
Source Yale University
Contact
Status Terminated
Phase N/A
Start date June 1, 2018
Completion date March 8, 2022
View Details
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