Post-traumatic Stress Disorder Clinical Trial
Official title:
Prevention of Post Traumatic Stress Disorder by Early Treatment
To prospectively evaluate the effect of early treatment (cognitive therapy (CT), cognitive-behavioral therapy (CBT) and escitalopram (SSRI) in preventing the occurrence of post-traumatic stress disorder in recent survivors of traumatic events.
Status | Completed |
Enrollment | 298 |
Est. completion date | January 2008 |
Est. primary completion date | January 2008 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Adults survivors of traumatic events Exclusion Criteria: - Traumatic brain injury - Lifetime psychosis - Life time (prior) PTSD - Medical conditions forbidding SSRIs |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Israel | Hadassah Medical Organization Jerusalem Israel | Jerusalem |
Lead Sponsor | Collaborator |
---|---|
Hadassah Medical Organization |
Israel,
Shalev AY, Ankri Y, Israeli-Shalev Y, Peleg T, Adessky R, Freedman S. Prevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study. Arch Gen Psychiatry. 2012 Feb;69(2):166-76. doi: 10.1001 — View Citation
Shalev AY, Ankri YL, Peleg T, Israeli-Shalev Y, Freedman S. Barriers to receiving early care for PTSD: results from the Jerusalem trauma outreach and prevention study. Psychiatr Serv. 2011 Jul;62(7):765-73. doi: 10.1176/appi.ps.62.7.765. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Post-traumatic Stress Disorder (chronic) by CAPS scores. | Four months, seven months, 14 moths, two years | No | |
Secondary | Symptoms of post-traumatic Stress Disorder per PSS-SR (questionnaire) and CAPS (structured interview) | Four months, seven months, 14 moths, two years | No | |
Secondary | Symptoms of depression as per the Beck Depression Inventory (BDI) | Four months, seven months, 14 moths, two years | No |
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