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Post-Traumatic Stress Disorder clinical trials

View clinical trials related to Post-Traumatic Stress Disorder.

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NCT ID: NCT05562973 Withdrawn - Clinical trials for Post-Traumatic Stress Disorder

Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder

Start date: January 2025
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, and potential efficacy of psilocybin-assisted psychotherapy to reduce post-traumatic stress disorder (PTSD) severity in a sample of individuals with PTSD.

NCT ID: NCT05386862 Withdrawn - Clinical trials for Post Traumatic Stress Disorder

Warrior CARE: Naturalistic Observation and Harm Reduction

NOC
Start date: July 13, 2022
Phase: N/A
Study type: Interventional

This study is looking at therapeutic potential of reducing Tetrahydrocannabinol (THC) levels in regular cannabis smokers using contingency management (CM) intervention in a U.S. veteran population with post-traumatic stress disorder (PTSD).

NCT ID: NCT04875221 Withdrawn - PTSD Clinical Trials

Network-based Neurofeedback in PTSD

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

This project will examine the use of real-time fMRI (rt-fMRI) neurofeedback in the regulation of neural networks underlying symptoms experienced by individuals with posttraumatic stress disorder (PTSD). Investigators will use rt-fMRI neurofeedback in order to facilitate emotion regulation during symptom induction, and examine individual differences that influence regulation capacities.

NCT ID: NCT04664907 Withdrawn - Clinical trials for Post Traumatic Stress Disorder

Videomusic and Psychic Trauma

VIMUTRAU
Start date: January 2021
Phase: N/A
Study type: Interventional

This project is interested in the flow of consciousness and its modalizations during psychological trauma (post-traumatic stress disorder) and its resolution. It is based on the premise that in PTSD, consciousness becomes more rigid, less fluid, due to the memory always imposing itself on the consciousness. The resolution of the trauma and the subsequent reduction of anxiety might improve the fluidity of consciousness and thus lead to an overall improvement in the psychological state of PTSD patients. In cases of PTSD, music has been shown to reduce anxiety from the very first session and has a very positive effect on all PTSD symptoms. In this project the following elements will be evaluated : on one hand, the changes in consciousness and its fluidity and, on the other hand, the evolution of anxiety following the listening of a new kind of work, videomusic (which associates a video scenario with music) exemplifying (metaphorizing) the trauma and its resolution.

NCT ID: NCT04654130 Withdrawn - PTSD Clinical Trials

Neurofeedback Effectiveness Trial in PTSD

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

This study is an effectiveness trial investigating neurofeedback (NFB) in adults with PTSD (Post-Traumatic Stress Disorder). Participants will be randomly assigned to one of two treatment conditions - i) NFB, or ii) wait list. Due to the coronavirus pandemic, our study will, primarily, take place online (i.e., online assessment and treatment, with option of in-person fMRI, or functional magnetic resonance imaging, scans). NFB sessions will be conducted from home, with videoconferenced supervision by research staff. After study completion, individuals in the wait list condition will be offered the same NFB treatment.

NCT ID: NCT04592159 Withdrawn - Clinical trials for Post-Traumatic Stress Disorder

Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress Disorder

Start date: February 1, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

This study will be conducted to evaluate the efficacy of nabiximols for the treatment of symptoms of post-traumatic stress disorder (PTSD) in participants receiving selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) pharmacotherapy.

NCT ID: NCT04496557 Withdrawn - Clinical trials for Post-traumatic Stress Disorder

Feasibility Open Label Study Evaluating The Use Of Process-Instructed Self Neuro-Modulation (PRISM) For Post-Traumatic Stress Disorder

PRISM
Start date: October 1, 2020
Phase: N/A
Study type: Interventional

This is a single-arm, open-label feasibility study. A maximum of 15 participants will be enrolled. All participants will undergo a novel neurofeedback intervention, targeting down-regulation of deep limbic structures, specifically the amygdalae. Participants will complete 12 neurofeedback sessions delivered twice weekly over 6 consecutive weeks. The intervention will be delivered via the PRISM platform.

NCT ID: NCT04464148 Withdrawn - Clinical trials for Alcohol Use Disorder

Feasibility Trial of Pregnenolone for Posttraumatic Stress Disorder and Alcohol Use Disorder

Start date: December 2021
Phase: Phase 1
Study type: Interventional

Pregnenolone is a neurosteroid and an over-the-counter supplement that has shown promise in clinical studies of stress-related disorders, such as anxiety, depression and posttraumatic stress disorder (PTSD). Epidemiological studies suggest that patients with PTSD are at higher risk of developing addiction, including alcohol use disorder (AUD).The following hypothesis will be tested in this trial: pregnenolone is associated with a reduction in both PTSD symptoms and the number of standard drinks per week in outpatients with PTSD and AUD.

NCT ID: NCT04457271 Withdrawn - Clinical trials for Cognitive Impairment

Goal Management Training in Individuals With PTSD

Start date: January 2023
Phase: N/A
Study type: Interventional

This study will evaluate the effect of a manualized treatment (Goal Management Training, or GMT) on the cognitive impairments associated with PTSD (Post-Traumatic Stress Disorder), as well as any impact on PTSD symptems themselves. Participants will be randomized to either GMT group treatment, or a wait list condition.

NCT ID: NCT04299841 Withdrawn - Clinical trials for Post Traumatic Stress Disorder

Observational Study of the Evaluation of Post Traumatic Stress Post Stroke

SPTD
Start date: March 2021
Phase:
Study type: Observational

This prospective, observational, multicentre study evaluates the existence of Post-traumatic stress disorder following a stroke at 3 and 6 months after the management of the patient. Questionnaires will be used to assess the presence of stroke post traumatic disorder. The evaluation of stroke post traumatic disorder would allow to underline the importance of the awareness of the care teams in the the screening of these disorders and to evaluate if the Post-traumatic Stress Disorder Checklist Scale (PCL5) is an effective screening tool.