Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT04531553 |
Other study ID # |
ESPB for PTPS |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
March 3, 2021 |
Est. completion date |
June 15, 2022 |
Study information
Verified date |
July 2022 |
Source |
National Cancer Institute, Egypt |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The thoracic epidural block (TEB) and thoracic paravertebral block (TPVB) are the most
commonly used techniques for analgesia after thoracic surgery.Recently, erector spinae plane
block (ESPB) was reported as a treatment for thoracic neuropathic pain.Dexmedetomidine has
been primarily used for intra- venous sedation in intensive care settings. The unique
analgesic properties of dexmedetomidine have encouraged the anesthesiologists to use it
perineurally.
This study aims to evaluate the effect ultrasound erector spinae plane block with
dexmedetomidine infusion in management of acute and chronic post thoracotomy pain.
Description:
The thoracic epidural block (TEB) and thoracic paravertebral block (TPVB) are the most
commonly used techniques for analgesia after thoracic surgery. However, TEA has several
adverse effects, such as hypotension, motor blockade, hematoma, and abscess and TPVB has a
chance of epidural spread and pneumothorax, and multiple injections are needed if more than 4
dermatome analgesia is required. Recently, erector spinae plane block (ESPB) was reported as
a treatment for thoracic neuropathic pain.
ESPB is a relatively simple technique with easily identified sonographic landmarks, and a
catheter is easily inserted into the plane after distention induced by the injection.
Additionally, the ESPB has the potential to provide both somatic and visceral sensory
blockade.
The selectivity of dexmedetomidine to the α2-receptors is eight times of its prototype,
clonidine. Accordingly, dexmedetomidine is a more powerful sedative and analgesic drug than
clonidine with less hemodynamic derangements from the α1-receptor activation. Dexmedetomidine
has been primarily used for intra- venous sedation in intensive care settings. The unique
analgesic properties of dexmedetomidine have encouraged the anesthesiologists to use it
perineurally. Previous studies have declared that dexmedetomidine potentiates local
anesthetic effect when administered by neuroaxial route.
This study aims to evaluate the effect ultrasound erector spinae plane block with
dexmedetomidine infusion in management of acute and chronic post thoracotomy pain.