Intravenous Immunoglobulins for Post-Polio Syndrome

Status Completed

Clinical Trial Summary

Postpolio syndrome is a condition that affects many polio survivors years after the acute infection and causes symptoms to increase or new symptoms to develop. Proinflammatory cytokine production within the central nervous system (CNS) indicates an underlying inflammatory process, amenable to immunomodulatory therapy. In this study the investigators sought to confirm that antiinflammatory treatment with intravenous immunoglobulin improves the disease.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01537575
Study type	Interventional
Source	Azienda Ospedaliera Universitaria Integrata Verona
Contact
Status	Completed
Phase	Phase 3
Start date	January 2008

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT02176863` - Study of the Efficacy and Safety of Immune Globulin Intravenous (Human) Flebogamma® 5% DIF in Patients With Post-polio Syndrome	Phase 2/Phase 3
Active, not recruiting	`NCT03561623` - Spinal Cord Gray Matter Imaging in Post Polio Syndrome
Completed	`NCT02815878` - Enhance Wellness for Individuals With Long-Term Physical Disabilities	N/A
Recruiting	`NCT05644522` - Nomad P-KAFO Study	N/A
Completed	`NCT02801071` - L-Citrulline in Patients With Post-Polio Syndrome	Phase 3
Completed	`NCT03064711` - Activity and Fatigue of the Respiratory Muscles and Pulmonary Characteristics in Post-Polio Patients	N/A
Active, not recruiting	`NCT02089880` - Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis	N/A
Completed	`NCT01402570` - Glutathione and Health With Post-Polio Syndrome	N/A
Completed	`NCT00231439` - Post-Poliosyndrome Treated With Intravenous Immunoglobulin (IvIg)	Phase 2/Phase 3