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Post-Polio Syndrome clinical trials

View clinical trials related to Post-Polio Syndrome.

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NCT ID: NCT03561623 Active, not recruiting - Post-polio Syndrome Clinical Trials

Spinal Cord Gray Matter Imaging in Post Polio Syndrome

Start date: May 22, 2017
Study type: Observational

This is a longitudinal, observational study with the aims of comparing spinal cord gray matter areas in patients with Post-Polio Syndrome to age and sex matched healthy control subjects and to correlate atrophy with metrics of clinical disability.

NCT ID: NCT03064711 Completed - Post-polio Syndrome Clinical Trials

Activity and Fatigue of the Respiratory Muscles and Pulmonary Characteristics in Post-Polio Patients

Start date: January 2013
Phase: N/A
Study type: Interventional

Background: Early diagnosis of respiratory impairment in Post-Polio (PPS) patients may delay respiratory decline and future need of invasive respiratory aids. Objectives: To compare pulmonary function measures, maximal respiratory pressure and activity levels and fatigue of respiratory muscles between patients with PPS and healthy controls. Design: Cross-sectional study. Setting: Hadassah physical medicine and rehabilitation department, Jerusalem. Patients: Patients with PPS (N=12; 6 males; age 62.1±11.6 years) able to walk for 6 minutes without human assistance; age-matched healthy subjects (N=12; 4 males; age 62.2±6.5 years). Intervention: None. Measurements: A body plethysmograph was used to quantify forced expiratory volume in the first second of a forced expiratory maneuver, vital capacity, slow vital capacity, Residual Volume (RV), Total Lung Capacity (TLC), and Thoracic Gas Volume (TGV). Also, RV to TLC ratio is calculated. A manometer was used to measure Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP). A spirometer was used to measure Maximal Voluntary Ventilation (MVV). Surface electromyography (sEMG) recorded diaphragmatic muscle activity during rest and while performing MVV.

NCT ID: NCT02815878 Completed - Multiple Sclerosis Clinical Trials

Enhance Wellness for Individuals With Long-Term Physical Disabilities

Start date: May 12, 2014
Phase: N/A
Study type: Interventional

This project is an adaptation trial, testing the efficacy of an evidence-based community wellness program, Enhance Wellness (, in a sample of middle and older-aged adults living with multiple sclerosis, spinal cord injury, post-polio syndrome and muscular dystrophy.

NCT ID: NCT02801071 Active, not recruiting - Post-Polio Syndrome Clinical Trials

L-Citrulline in Patients With Post-Polio Syndrome

Start date: June 2016
Phase: Phase 3
Study type: Interventional

The purpose of the study is to show that the intake of L-citrulline improves muscle function in patients with Post-Polio Syndrome (PPS).

NCT ID: NCT02176863 Recruiting - Post-polio Syndrome Clinical Trials

Study of the Efficacy and Safety of Immune Globulin Intravenous (Human) Flebogamma® 5% DIF in Patients With Post-polio Syndrome

Start date: September 23, 2014
Phase: Phase 2/Phase 3
Study type: Interventional

This is a multicenter, prospective, randomized, placebo-controlled, double-blind, parallel group clinical trial with adaptive dose selection in subjects with post polio syndrome (PPS). The main purpose of this study is to select a dose of Flebogamma 5% DIF and confirm the efficacy of the selected Flebogamma® 5% DIF dose by assessing physical performance, as measured by 2 Minutes Walk Distance (2MWD) test. The study will consist of 2 stages, with each stage consisting of a screening period (up to 4 weeks), a treatment period (52 weeks), and a follow-up period (24 weeks).

NCT ID: NCT02089880 Active, not recruiting - Clinical trials for Spinal Cord Injuries

Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis

Start date: February 2014
Phase: N/A
Study type: Interventional

The study will specifically evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to neurologic or neuromuscular disease, orthopedic disease or trauma, as compared to the stance control orthosis.

NCT ID: NCT01537575 Completed - Post-polio Syndrome Clinical Trials

Intravenous Immunoglobulins for Post-Polio Syndrome

Start date: January 2008
Phase: Phase 3
Study type: Interventional

Postpolio syndrome is a condition that affects many polio survivors years after the acute infection and causes symptoms to increase or new symptoms to develop. Proinflammatory cytokine production within the central nervous system (CNS) indicates an underlying inflammatory process, amenable to immunomodulatory therapy. In this study the investigators sought to confirm that antiinflammatory treatment with intravenous immunoglobulin improves the disease.

NCT ID: NCT01402570 Completed - Pain Clinical Trials

Glutathione and Health With Post-Polio Syndrome

Start date: August 2011
Phase: N/A
Study type: Interventional

In this study, people who have symptoms of post polio will take oral glutathione supplements for three months. Their levels of fatigue, physical function, sleep disturbance, impairment and emotional distress will be measured with both subjective and objective measures.

NCT ID: NCT00231439 Completed - Post-Polio Syndrome Clinical Trials

Post-Poliosyndrome Treated With Intravenous Immunoglobulin (IvIg)

Start date: August 2003
Phase: Phase 2/Phase 3
Study type: Interventional

Inflammatory cytokines in the cerebrospinal fluid may contribute to the new muscle weakness, fatigue and pain experienced by patients with post-polio syndrome. Intravenousimmunoglobulin (IvIg) reduces this inflammation. The purpose of this study is to investigate the clinical effect of IvIg in post-polio syndrome.