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Clinical Trial Summary

Inflammatory cytokines in the cerebrospinal fluid may contribute to the new muscle weakness, fatigue and pain experienced by patients with post-polio syndrome. Intravenousimmunoglobulin (IvIg) reduces this inflammation. The purpose of this study is to investigate the clinical effect of IvIg in post-polio syndrome.


Clinical Trial Description

Post-polio syndrome (PPS) is characterised by new muscle weakness, pain, and fatigue several years after the attack of acute polio. This leads to increased disability, and up to now only supportive therapy is available.

Patients with PPS lose more motor neurons than expected and surviving neurons fail to maintain neurogenic supply to enlarged motor units. New data report an increased level of inflammatory cytokines in the cerebrospinal fluid (CSF). Immune modulating therapy like IvIg could be an option and this pilot study is the first to investigate the clinical effect of IvIg in PPS. In addition, levels of cytokines in CSF and serum before and after treatment will be investigated. ;


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00231439
Study type Interventional
Source Haukeland University Hospital
Contact
Status Completed
Phase Phase 2/Phase 3
Start date August 2003
Completion date July 2004

See also
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Completed NCT02801071 - L-Citrulline in Patients With Post-Polio Syndrome Phase 3
Completed NCT03064711 - Activity and Fatigue of the Respiratory Muscles and Pulmonary Characteristics in Post-Polio Patients N/A
Completed NCT01537575 - Intravenous Immunoglobulins for Post-Polio Syndrome Phase 3
Active, not recruiting NCT02089880 - Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis N/A
Completed NCT01402570 - Glutathione and Health With Post-Polio Syndrome N/A