Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage

Status Completed

Clinical Trial Summary

Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available. The aim of this study is to compare the safety and efficacy of Oxytocin and misoprostol for prevention of PPH.

Clinical Trial Description

In a double blind randomized controlled trial 400 pregnant women who has vaginal delivery at Shariati hospital are assigned into two groups either to receive 20 unite oxytocin in 1000cc ringer and 2 placebo tablet or 400mcg oral misoprostol and 2cc normal saline in 1000cc ringer. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01863706
Study type	Interventional
Source	Hormozgan University of Medical Sciences
Contact
Status	Completed
Phase	Phase 1
Start date	May 2013
Completion date	December 2013

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03680339` - The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS	Phase 4
Completed	`NCT03693599` - Carbetocin Versus Syntometrine in Obese Women Undergoing Elective Cesarean	Phase 4
Completed	`NCT03707132` - Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
Recruiting	`NCT02306733` - Ergometrine Versus Oxytocin in the Management of Atonic Post-partum Haemorrhage (PPH) in Women Delivered Vaginally	Phase 3
Completed	`NCT01866241` - Combating Maternal Mortality in Uganda: An Assessment of the Role of Misoprostol in Prevention of Post-Partum Hemorrhage	Phase 3
Not yet recruiting	`NCT01236482` - Oxytocin in Cesarean Delivery	Phase 4
Completed	`NCT03784794` - Patient Blood Management for Massive Obstetric Hemorrhage	N/A
Enrolling by invitation	`NCT06255496` - QStat Cartridge in Obstetric Patients
Recruiting	`NCT04401839` - Amr Maneuver for Prevention of Postpartum Hemorrhage	N/A
Recruiting	`NCT06219538` - DAISY Uterine Drain Device Evaluation	N/A
Not yet recruiting	`NCT06333340` - Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery	N/A
Terminated	`NCT04277962` - Estimating Blood Loss Using TritonTM in Vaginal Deliveries: A Validation Trial	N/A
Completed	`NCT04723979` - NovoSeven® in Severe Postpartum Haemorrhage - Experiences From UK, DK, FR, NL
Completed	`NCT03570723` - Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa	N/A
Completed	`NCT03117647` - Mansoura-VV Uterine Compression Suture for Primary Atonic Postpartum Hemorrhage	N/A
Active, not recruiting	`NCT03069859` - Use of TXA to Prevent Postpartum Hemorrhage	Phase 2
Not yet recruiting	`NCT03891082` - A Comparative Study Between Bakri Balloon and B Lynch Suture Used to Control Primary Postpartum Hemorrhage After Cesarean Section	N/A
Not yet recruiting	`NCT03463070` - Misoprostol Before and After Cesarean Section	Phase 3
Recruiting	`NCT05532215` - Sublingual Misoprostol in Reduction of Caesarean Blood Loss	N/A
Completed	`NCT03907605` - Anti-Mullerian Hormone (AMH) is a Marker for Ovarian Reserve. There Are Many Studies About AMH Changes in Ovarian Surgery, But Little is Known for Other Surgeries. We Seek to Investigate the Hormone Variations Before and After Uterine Artey Ligation for Postpartum Hemorrage (PPH)