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Post-Operative Ileus clinical trials

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NCT ID: NCT06413888 Completed - Clinical trials for Delayed Gastric Emptying

Nasogastric Decompression Following Pancreaticoduodenectomy

whipple
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Pancreaticoduodenectomy (PD) remains the gold-standard operation for peri-ampullary neoplasms. Traditionally, gastric decompression via nasogastric intubation has been employed postoperatively to prevent nausea, vomiting, aspiration pneumonia, anastomotic leakage and delayed gastric emptying. Recently, the implementation of ERAS protocol recommended against routine use of nasogastric tube following PD. however, limited data exists surrounding the identification of those patients needing NGT decompression in the immediate postoperative period. Therefore, we initiated a large prospective randomized controlled trial to evaluate the clinical outcomes of patients who retained the NGT post-PD versus those who had it removed at the end of the procedure. This study aims to assess the effectiveness of nasogastric decompression in PD recovery, with the primary endo point being the need for and impact of NGT in the postoperative recovery. The secondary endpoint will examined the re-insertion rate of NGT and identify factors that necessitate its use in the immediate postoperative period.

NCT ID: NCT04009954 Recruiting - Clinical trials for Post-operative Ileus

Post-operative Ileus and Gut Microbiota

Start date: April 1, 2019
Phase:
Study type: Observational

Postoperative ileus (POI) is a common clinical condition after abdominal surgical procedure, leading to increased patient morbidity and prolonged hospitalisation.The mechanism of POI is not very clear until now. At the end of the 20th century, the inflammatory-mediated ileus hypothesis was introduced. But the initial trigger of the inflammatory cascade is unclear.Previous study demonstrate a clear association between colonic transit time, gut microbiota composition and urinary metabolic phenotype. Here the investigators suggest that the perioperative gut microbiota may contribute to POI.

NCT ID: NCT03068975 Terminated - Clinical trials for Post Operative Ileus

Alvimopan Use in Polytraumatized Patients

Start date: September 1, 2017
Phase: Phase 4
Study type: Interventional

To evaluate the efficacy and safety of Alvimopan(12 mg) in recovery of bowel function in an emergency trauma setting without the pre-operative dosage in patients that will receive abdominal surgery.

NCT ID: NCT02673671 Recruiting - Clinical trials for Post-operative Ileus

G-Tech Feasibility Study for Early Detection of a Post-op Ileus

GTECHPOI
Start date: February 2016
Phase:
Study type: Observational

This feasibility study is for the purpose of determining if the G-Tech Device can differentiate between normal return of GI activity post-operatively and the myoelectric activity in patients who develop a POI.

NCT ID: NCT02065583 Recruiting - Clinical trials for Post Operative Ileus

Predictive Validity of Acoustic Gastrointestinal Surveillance (AGIS) in Post-Operative Feeding

AGIS
Start date: December 2013
Phase: N/A
Study type: Observational

This study will measure the accuracy of a disposable, non-invasive device for the continuous monitoring of abdominal sounds, called the AGIS sensor (Acoustic Gastro-Intestinal Surveillance) in predicting patients' intolerance to feeding (defined as severe nausea, vomiting, or need to place a nasogastric tube within 4 hours of initiating a standard feeding protocol) following abdominal surgery. This will be a pragmatic, observational study.

NCT ID: NCT01869231 Completed - Clinical trials for Post-operative Ileus

Evaluating the Efficacy of Current Treatments for Reducing Postoperative Ileus

Start date: April 2010
Phase: N/A
Study type: Interventional

Aim was to investigate efficacy of current treatments - water, chewing gum, and olive oil, in resolving postoperative ileus.

NCT ID: NCT01662115 Terminated - Clinical trials for Post-operative Ileus

Nicotine Gum Recovery After Colorectal Surgery

Start date: August 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate whether the use of nicotine gum in the postoperative period influences surgical outcome in patients undergoing colorectal surgery.

NCT ID: NCT01583452 Completed - Clinical trials for Post Operative Ileus

Chewing Gum Use to Reduce Post-operative Ileus in Pediatric Patients

Start date: April 2012
Phase: Phase 1
Study type: Interventional

Post- operative ileus refers to the time after surgery before coordinated electromotor bowel function resumes. It's treatment and prevention may signify an elevated hospitalization cost and the exposure to the patient to adverse effects of drugs. The current clinical trial has as primary objective to prove the efficacy of chewing gum as a preventive measure of post-operative ileus in pediatric patients after gastrointestinal surgery through the determination of the time the patient takes to tolerate oral intake, pass flatus, present bowel movements and the time of hospital stay. Patients will be assigned either to the case group (chewing gum + standard treatment) or to the control group (standard treatment), in both of them time from the end of surgery to the moment the patient presents first bowel movement, passes flatus, tolerates oral intake (any type of food) and is discharged from hospital; will be measured in hours and then analyzed to determine the validity of these data.

NCT ID: NCT00443040 Terminated - Clinical trials for Post-Operative Ileus

Asimadoline for the Treatment of Post-Operative Ileus

Start date: January 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of asimadoline in patients who have undergone a laparoscopic segmental colectomy and determine whether it reduces the time to recovery of bowel function compared to placebo.