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Clinical Trial Summary

XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature management [TTM]) to xenon by inhalation plus standard-of-care post-cardiac arrest intensive care (including TTM).


Clinical Trial Description

XePOHCAS:

Primary Objective:

To evaluate whether there is a difference in functional outcome with xenon 50% and oxygen during targeted temperature management (TTM) compared with similar oxygen content in air during TTM in comatose subjects with sustained restoration of spontaneous circulation (ROSC) within 30 minutes after out-of-hospital cardiac arrest (OHCA).

Secondary Objective:

To evaluate whether there is a difference in survival with xenon 50% and oxygen during targeted temperature management (TTM) compared with similar oxygen content in air during TTM in comatose subjects with sustained restoration of spontaneous circulation (ROSC) within 30 minutes after out-of-hospital cardiac arrest (OHCA). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03176186
Study type Interventional
Source NeuroproteXeon, Inc.
Contact Bill Stoll
Phone 7163327200
Email bill.stoll@npxe.com
Status Recruiting
Phase Phase 3
Start date December 20, 2018
Completion date December 15, 2020

See also
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Not yet recruiting NCT04859270 - The Holistic Health Care of Post-Cardiac Arrest Survivors: From Patient's Health to Family Resilience
Recruiting NCT05895838 - The Danish Out-of-Hospital Cardiac Arrest Study Phase 3