Post-Cardiac Arrest Syndrome Clinical Trial
Official title:
XePOHCAS - Xenon by Inhalation for Post Out of Hospital Cardiac Arrest Syndrome
XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature management [TTM]) to xenon by inhalation plus standard-of-care post-cardiac arrest intensive care (including TTM).
XePOHCAS:
Primary Objective:
To evaluate whether there is a difference in functional outcome with xenon 50% and oxygen
during targeted temperature management (TTM) compared with similar oxygen content in air
during TTM in comatose subjects with sustained restoration of spontaneous circulation (ROSC)
within 30 minutes after out-of-hospital cardiac arrest (OHCA).
Secondary Objective:
To evaluate whether there is a difference in survival with xenon 50% and oxygen during
targeted temperature management (TTM) compared with similar oxygen content in air during TTM
in comatose subjects with sustained restoration of spontaneous circulation (ROSC) within 30
minutes after out-of-hospital cardiac arrest (OHCA).
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