Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples

Port-Wine Stain Clinical Trial

Official title:

Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02051101
• Other study ID #: 20139396
• Status: Completed
• Phase: N/A
• Start date: April 23, 2013
• Est. completion date: January 11, 2019

Study information

• Verified date: October 2022
• Source: University of California, Irvine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the pathogenic mechanisms of Port Wine Stain, collect biopsy samples and blood samples to characterize exosomes and metabolites from Port Wine Stain.

Description:

The researcher can detect the defects in nervous system innervation to cutaneous blood vessels contribute to the pathogenesis of Port Wine Stain . Unveiling the pathogenic mechanisms of PWS is crucial to the design of new therapeutic strategies and can use the results to improve current PWS therapeutic outcomes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: January 11, 2019
• Est. primary completion date: January 11, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 1 Day and older

Eligibility

Inclusion Criteria:

• Male or female of all ages.
• Not pregnant.
• Has diagnosis of port wine stain on the arms, legs, chest, bac.
• Ability to understand and carry out subject instructions.
• Subject willing to have skin biopsies on port wine stain and normal skin areas.

Exclusion Criteria:

• Pregnant women.
• Port Wine Stain on the face.
• History of skin cancer.
• Current participation in an investigational drug evaluation
• Concurrent use of known photosensitizing drugs.

Related Conditions & MeSH terms

• Hemangioma, Capillary
• Port-Wine Stain

Intervention

Other:
• Biopsy sample from Port Wine Stain Birthmark
Biopsy sample from Port Wine Stain Birthmark

Locations

Country	Name	City	State
United States	Beckman Laser Institute	Irvine	California

Sponsors (2)

Lead Sponsor	Collaborator
University of California, Irvine	Beckman Laser Institute University of California Irvine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Characterization of Port Wine Stain Birthmark tissue sample		up to 4 weeks