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Porphyria, Acute Intermittent clinical trials

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NCT ID: NCT06273644 Recruiting - Clinical trials for Porphyria, Acute Intermittent

Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment

Start date: January 27, 2024
Phase: N/A
Study type: Interventional

The main aim of this clinical trial is to learn about the effect of carbohydrate-rich diet as a treatment for AIP (acute intermittent porphyria). Aim: Investigate the diet's impact on tissue and serum glucose, plasma insulin, cytokine levels, amino acids, and gut microbiota in AIP, and their correlation with PBG (Porphobilinogen). Aim: Assess the diet's effect on AIP symptoms and health status in AIP. Aim: Measure the effect of a high-carbohydrate diet on mitochondrial activity in AIP Aim: Map and detect potential mutations in mitochondrial genomic DNA in AIP Aim: Discover new markers in AIP through RNA sequencing and machine learning. Participants will follow two diet plans, a 4-week intervention with 60-65 E% carbohydrates and a 4 week intervention with 40-45 E% carbohydrates.

NCT ID: NCT05502133 Recruiting - Clinical trials for Acute Intermittent Porphyria (AIP)

Identification of Acute Intermittent Porphyria Modifying Genes

Start date: September 23, 2022
Phase:
Study type: Observational

This study proposes to identify the predisposing/protective modifying genes that underlie the acute attacks in symptomatic patients with Acute Intermittent Porphyria (AIP), an autosomal dominant inborn error of heme biosynthesis.

NCT ID: NCT01561157 Recruiting - Acute Porphyrias Clinical Trials

Longitudinal Study of the Porphyrias

Start date: November 1, 2010
Phase:
Study type: Observational

The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders.