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Poor Responders clinical trials

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NCT ID: NCT05900661 Not yet recruiting - Poor Responders Clinical Trials

The Effect of Myo-inositol, Somatropin, and DHEA on Poor Ovarian Responders

Start date: July 30, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

To evaulate the role of Myo-inositol, somatropin, DHEA on ICSI outcome in poor ovarian responder

NCT ID: NCT04487925 Recruiting - IVF Clinical Trials

Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders

MONACO
Start date: January 25, 2022
Phase: Phase 4
Study type: Interventional

This is a prospective, randomized, single center, phase 4 controlled trial. The study will compare the efficacy of two different strategies for the management of predicted poor response patients under stimulation for IVF/ICSI: up to three MNC cycles (group 1) versus a single GnRH antagonist CFA (group 2).

NCT ID: NCT03438812 Completed - Poor Responders Clinical Trials

Dehydroepiandrosterone Maintain Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders

Start date: September 6, 2017
Phase: N/A
Study type: Interventional

To investigate whether the DHEA supplementation could improve mitochondrial quality in poor ovarian responders

NCT ID: NCT02201914 Recruiting - IVF Clinical Trials

Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF

Start date: January 2014
Phase: Phase 4
Study type: Interventional

Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition, due to its poor prognosis in terms of chances of pregnancy and live births. Various ovarian stimulation regimens have been tried to overcome these obstacles. A simple approach is increase the dose of the gonadotropin administration, but the results in terms of pregnancy rate are very low Another commonly used stimulation regimen is the microdose GnRH agonist protocol, which takes advantage of the initial rise in endogenous gonadotropins that follows the agonist administration in the early follicular phase and subsequently prevents a premature LH surge, with fewer cycle cancellations. However, their application in poor responders, even if in small doses and for a limited period, has been questioned as they may cause oversuppression of ovarian function, leading to a prolonged cycle and increased treatment costs without improving the outcomes. Recently, GnRH antagonists were introduced in ART treatment. They are effective in preventing a premature LH surge and allow for a more natural recruitment of follicles in the follicular phase in a non-suppressed ovary, offering a potential alternative in the treatment of these patients. However, randomized studies evaluating the efficacy of this regimen in poor responders did not show any improvements in pregnancy rates. Current approach have included the addition of oral agents such us clomiphene citrate (CC) to gonadotropins. Some authors have investigated the role of CC in addition to low dose of gonadotropins in mild stimulation regimen, demonstrating that, despite a small number of retrieved oocytes, good quality embryos were produced with a subsequent improvement in the fertilization rate, clinical pregnancy rate and live birth rate. The only study that evaluate the efficacy of CC in addition to high doses of gonadotropins in poor responders showed improving in number of retrieved oocytes, transferred embryos and biochemical pregnancy; however, clinical pregnancy rate and live birth rate remained low and showed no measurable increase. The aim of this study was to compare the efficacy of the CC as an adjunctive to a high dose of gonadotropins in cycles with antagonist protocols with the microdose GnRH agonist and flexible antagonist protocols in women who responded poorly to ovarian stimulation, to determine whether this protocol may improve IVF outcomes, offering a valid alternative in poor responder patients treatment.

NCT ID: NCT02158689 Completed - Poor Responders Clinical Trials

Comparison of Treatment Modalities in Poor Responders Undergoing IVF

Start date: June 2014
Phase: N/A
Study type: Interventional

The accurate identification and efficient management of poor responders remains one of the most enigmatic challenges in assisted reproductive technology (ART). The investigators study will compare the letrozole/antagonist protocol to the hMG/antagonist protocol in women who poor responders.