Dehydroepiandrosterone Maintain Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders

Poor Responders Clinical Trial

Official title:
The Role of Dehydroepiandrosterone in the Maintenance of Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders

Status Completed

Clinical Trial Summary

To investigate whether the DHEA supplementation could improve mitochondrial quality in poor ovarian responders

Clinical Trial Description

Women who underwent in vitro fertilization (IVF) treatment participated, including normal ovarian responders (NORs) and poor ovarian responders (PORs). PORs were assigned to receive DHEA supplementation or not before the IVF cycle. For all patients, cumulus cells (CCs) were obtained after oocyte retrieval. In the CCs, mRNA expression of mitochondria-related genes was measured. To compare the mRNA expression of mitochondria-related genes in the CCs among the three groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03438812
Study type	Interventional
Source	Kaohsiung Veterans General Hospital.
Contact
Status	Completed
Phase	N/A
Start date	September 6, 2017
Completion date	December 31, 2019

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See also
Status	Clinical Trial	Phase
Completed	`NCT02158689` - Comparison of Treatment Modalities in Poor Responders Undergoing IVF	N/A
Not yet recruiting	`NCT05900661` - The Effect of Myo-inositol, Somatropin, and DHEA on Poor Ovarian Responders	Phase 2/Phase 3
Recruiting	`NCT04487925` - Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders	Phase 4
Recruiting	`NCT02201914` - Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF	Phase 4