Clinical Trials Logo

Clinical Trial Summary

Reproductive age women diagnosed with poor ovarian response (POR) based on Bologna criteria with a history of at least two prior failed ICSI cycle will be recruited for the study. Antral follicle count (AFC), serum anti-mullerian hormone (AMH), and early follicular phase serum follicle stimulating hormone (FSH) levels will determined at baseline. Autologous blood obtained from peripheral vein will be used to prepare PRP following standard protocols and will be injected to both ovaries. Ovarian reserve parameters and ICSI outcomes will be determined.


Clinical Trial Description

Reproductive age women diagnosed with POR based on Bologna criteria with a history of at least two prior failed intracytoplasmic sperm injection (ICSI) cycle will recruited for the study. Antral follicle count (AFC), serum anti-mullerian hormone (AMH), and early follicular phase serum follicle stimulating hormone (FSH) levels will be determined at baseline. Autologous blood obtained from peripheral vein will be used to prepare PRP following standard protocols. PRP injection will be performed under sedation anesthesia, using a 11.8 inch (30 cm) single lumen 21G needles under transvaginal ultrasound guidance. On the 2 to 4th days of the first three menstrual cycles following the procedure, AFC, AMH, and FSH levels will be re-assessed. Patients with at least one antral follicle will be started on ovarian stimulation for ICSI, followed by embryo transfer. Biomarkers of ovarian reserve (AFC, FSH, AMH), and ICSI outcome parameters (number of metaphase II (MII) oocytes, blastocyst embryos, fertilization rate, oocyte and embryo quality) will be followed. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04797377
Study type Interventional
Source Nadezhda Women's Health Hospital
Contact
Status Completed
Phase N/A
Start date March 16, 2021
Completion date September 4, 2021

See also
  Status Clinical Trial Phase
Completed NCT01204840 - Growth Hormone for Poor Responders in in Vitro Fertilization (IVF) Phase 2
Completed NCT04224818 - Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders Phase 3
Recruiting NCT05602090 - Growth Hormone For Poor Ovarian Reserve Patients in ICSI Trials Phase 2/Phase 3
Not yet recruiting NCT04588844 - Effect of Growth Hormone Injection on the IVF/ICSI Outcome of Patients With Poor Ovarian Reserve. N/A