Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders

Poor Ovarian Reserve Clinical Trial

Official title: Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders: A Prospective Randomized Controlled Trial

Status Completed

Clinical Trial Summary

This is a randomized controlled clinical trial to investigate the effect of dual trigger (hCG and GnRH agonist) on the final oocyte maturation compared to the standard hCG trigger in patients with poor ovarian reserve seeking IVF/ICSI treatment.

Clinical Trial Description

Women with POR (Bologna criteria) manifest a very low follicular response to controlled ovarian stimulation irrespective of the stimulation protocol utilized. Dual triggering of oocyte maturation was shown to improve follicle collection yield and oocyte maturation in women with predicted normal ovarian response. These benefits have been attributed to the GnRHa-induced FSH surge believed to promote oocyte nuclear maturation and cumulus expansion. The aim of the study is to show whether the co-administration of a GnRH agonist and hCG for final oocyte maturation improve oocyte collection and maturation rate ;

Related Conditions & MeSH terms

• Poor Ovarian Reserve

• NCT number: NCT04224818
• Study type: Interventional
• Source: American University of Beirut Medical Center
• Status: Completed
• Phase: Phase 3
• Start date: July 11, 2018
• Completion date: August 30, 2019