Graft-versus-host Disease Clinical Trial
Official title:
Infusion of Mesenchymal Stem Cells as Treatment for Steroid-Resistant Grade II to IV Acute GVHD or Poor Graft Function: a Multicenter Phase II Study
The present project aims at investigating the role of MSC for the treatment of patients with Part 1: Steroid-refractory grade II-IV acute GVHD. Part 2: Poor graft function (PGF) Part 3: Low or falling donor T-cell chimerism after allogeneic HCT. This is a multicenter phase II study examining the feasibility and efficacy of this approach.
Part 1: complete recruitment Part 2: complete recruitment Part 3: recruiting ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT01428973 -
Minitransplants With HLA-matched Donors : Comparison Between 2 GVHD Prophylaxis Regimens
|
Phase 2 | |
Not yet recruiting |
NCT00749164 -
Allogeneic Mesenchymal Stem Cell for Graft-Versus-Host Disease Treatment
|
Phase 1/Phase 2 | |
Completed |
NCT00993343 -
Randomized Trial Comparing Sirolimus and Tacrolimus Versus Cyclosporine and Methotrexate as Graft-versus-host Disease (GVHD) Prophylaxis After Allogeneic Stem Cell Transplantation
|
Phase 3 | |
Completed |
NCT00360685 -
Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX
|
N/A | |
Active, not recruiting |
NCT04503616 -
Cyclophosphamide, Abatacept, and Tacrolimus for GvHD Prevention
|
Phase 1/Phase 2 | |
Terminated |
NCT02080195 -
Nonmyeloablative Conditioning and Transplantation for Patients With Refractory Systemic Lupus Erythematosus (SLE)
|
Phase 1/Phase 2 | |
Completed |
NCT02193880 -
Safety of Post-transplant Alpha-beta Depleted T-cell Infusion Following Haploidentical Stem Cell Transplant (Haplo SCT)
|
N/A | |
Completed |
NCT02942173 -
CD45RA Depleted T-cell Infusion for Prevention of Infections After TCRab/CD19-depleted Allo-HSCT
|
Phase 2/Phase 3 | |
Completed |
NCT02145403 -
Phase 1/2 Study of Carfilzomib for the Prevention of Relapse and GVHD in Allo-HCT for Hematologic Malignancies
|
Phase 1/Phase 2 | |
Recruiting |
NCT01941394 -
Mesenchymal Stem Cells Infusion for aGVHD Prophylaxis Transplantation
|
Phase 2 | |
Completed |
NCT00141713 -
The Use of Etanercept (Enbrel®) in the Treatment of Acute Graft-Versus-Host Disease
|
Phase 2 | |
Recruiting |
NCT01991301 -
Carfilzomib for the Prevention of Graft Versus Host Disease
|
Phase 1 | |
Completed |
NCT00408928 -
Study on the Safety and Effectiveness of VELCADE® in the Treatment of Graft-Versus-Host Disease
|
Phase 2 | |
Completed |
NCT01633229 -
Bone Marrow Stromal Cell Infusions for Stem Cell Transplant Complications
|
Phase 1 | |
Completed |
NCT05856058 -
To Assess SHR0302 Oral Solutions and Tablets in Healthy Subjects Clinical Studies of Relative Bioavailability
|
Phase 1 | |
Completed |
NCT02342613 -
Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation
|
Phase 1 | |
Recruiting |
NCT06423131 -
Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT
|
N/A | |
Completed |
NCT02144025 -
Prevention of Ocular Graft-Versus-Host Disease With Topical Cyclosporine in Recipients of Allogeneic HSCT
|
Phase 2 | |
Completed |
NCT01369914 -
The Natural History of Graft-Versus-Host Disease in the Eyes
|
||
Completed |
NCT00806728 -
Study of MEDI-507 in With Steroid-Resistant Acute Graft-Versus-Host Disease
|
Phase 1 |