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Allogeneic Mesenchymal Stem Cell for Graft-Versus-Host Disease Treatment — MSCGVHD  

Graft-Versus-Host Disease Clinical Trial

Official title:
Allogeneic Mesenchymal Stem Cell Infusion for Treatment Of Steroid Resistant GVHD

Clinical Trial Summary

Now it is commonly accepted that MSC produce an immune-tolerant environment in different settings. It has been shown (mainly for BM-MSC) that MSC can down-regulate T cells activation. This characteristic of BM derived MSC already has clinical implications and shows their potent effectiveness both in prophylaxis and treatment of resistant GvHD. Ongoing clinical trials of use bone marrow MSC for treatment of steroid resistant GvHD are successfully run on and some bone marrow donor registries included BM-MSC as a material for donation. According to our preclinical studies MSC from cells from marrow, placenta, umbilical cord vessels demonstrate similar pronounced immunosuppressive effect both with autologous and allogeneic lymphocytes. Our preliminary clinical experience shows that BM-MSC is an effective tool for treatment of steroid resistant GVHD. Present study aimed to demonstrate if human UC-MSC has in vivo immunosuppressive effect and can be used for GVHD treatment

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00749164
Study type Interventional
Source Hadassah Medical Organization
Contact Prof. Igor B. Resnick, MD, PhD, DSci
Phone 972-2-6778353
Email gashka@hadassah.org.il
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date September 2009
Completion date August 2012
View Details
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