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Dynamic Respiratory Muscle Function in Late-Onset Pompe Disease — DRMF  

Pompe Disease Clinical Trial

Official title:
Dynamic Respiratory Muscle Function in Late-Onset Pompe Disease

Clinical Trial Summary

This study intends to evaluate dynamic respiratory motor performance as a valuable measure of pulmonary function in adults with late-onset Pompe disease. The investigators will adopt a strategy that includes comprehensive evaluations of respiratory volume, flow, and timing parameters during resting and loaded breathing. These evaluations will then be associated to the standard clinical measure of maximal inspiratory pressure, the static inspiratory muscle function, as well as magnetic resonance imaging of thoracic expansion and diaphragmatic descent at rest and with exertion. Outcomes in participants with late-onset Pompe disease will be contrasted to the function of age- and gender-matched control subjects. This approach will enable the investigators to evaluate the relationship between dynamic diaphragmatic function and respiratory motor function.

Clinical Trial Description

The following tests will be completed over a two-day period: Respiratory pressure tests, breathing test, magnetic resonance imaging and magnetic resonance spectroscopy (MRI and MRS). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02354664
Study type Observational
Source University of Florida
Contact
Status Completed
Phase
Start date April 2015
Completion date October 19, 2016
View Details
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