Clinical Trials Logo
  1. Home
  2. Polypharmacy
  3. NCT03133182
  4. Details
NCT03133182 Clinical Trial

Polypharmacy and Outcomes After Elective Noncardiac Surgery

Polypharmacy Clinical Trial

Official title:
Association of Polypharmacy With Outcomes After Elective Noncardiac Surgery: a Population-based Cohort Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03133182
Other study ID # DM5
Secondary ID
Status Completed
Phase N/A
First received April 18, 2017
Last updated April 25, 2017
Start date April 2002
Est. completion date March 2014

Study information
Verified date April 2017
Source Ottawa Hospital Research Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program

Description:

Multilevel multivariable regression analysis will be used to investigate the adjusted association between preoperative polypharmacy and postoperative outcomes and healthcare resource utilization. Sensitivity analyses will be used to evaluate the robustness of the primary analysis.

Recruitment information / eligibility
Status Completed
Enrollment 200000
Est. completion date March 2014
Est. primary completion date March 2014
Accepts healthy volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Intermediate to high risk elective non-cardiac surgery

- Age >=66 on day of surgery

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Polypharmacy
Patients who are taking >=5 unique prescription drugs in the 3 months prior to surgery

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Ottawa Hospital Research Institute

Outcome
Type Measure Description Time frame Safety issue
Primary Mortality death from any cause from day of surgery up to 90 days after surgery
Secondary Complications Patient with a complication based on clusters of ICD-10 Type 2 codes collected in the hospital record From day of surgery to day of hospital discharge, up to 365 days after surgery
Secondary Length of stay Number of days in hospital after surgery date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
Secondary Costs of care Costs related to medical care paid for by the provincial health insurance system date of surgery up to 90 days after surgery
Secondary Institutional discharge A discharge location at the end of the surgical episode of care that is not back to the patient's original residence (specifically respite or long term care) date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
Secondary Hospital readmission Acute hospital readmission after discharge from index hospitalization From the date of hospital discharge to 30 days after the date of discharge
See also
  Status Clinical Trial Phase
Completed NCT03688542 - Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module N/A
Completed NCT02545257 - Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Care N/A
Withdrawn NCT01932632 - Medication Minimization for Long-term Care Residents N/A
Recruiting NCT04615065 - Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Active, not recruiting NCT04181879 - Appropriate Polypharmacy in Older People in Primary Care N/A
Not yet recruiting NCT03283735 - Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal N/A
Completed NCT02918058 - Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults N/A
Completed NCT03655405 - Randomised, Controlled Trial of an Individual Deprescribing Intervention for Nursing Homes Residents N/A
Completed NCT04575155 - Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management N/A
Withdrawn NCT05816967 - Rationalisation of Polypharmacy by the RASP-instrument and Discharge Counselling of Geriatric Inpatients N/A
Completed NCT05616689 - Bundled Hyperpolypharmacy Deprescribing N/A
Terminated NCT04055896 - Team Approach to Polypharmacy Evaluation and Reduction in a Long-Term Care Setting N/A
Active, not recruiting NCT03052192 - Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
Completed NCT02866799 - Multi-PAP: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy N/A
Completed NCT01732302 - Educational Intervention to Reduce Drug-related Hospitalizations in Elderly Primary Health Care Patients N/A
Enrolling by invitation NCT05053815 - Pharmacogenomic Testing in a Program of All-inclusive Care for the Elderly (PACE) Setting
Active, not recruiting NCT04585191 - Reducing Treatment Risk in Older Adults With Diabetes N/A
Active, not recruiting NCT04120480 - Effectiveness of PGx Testing N/A
Recruiting NCT05609981 - Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems N/A
Recruiting NCT05501223 - Physician-initiated Medication Review in a Type 2 Diabetes Outpatient Clinic N/A