Effectiveness of PGx Testing

Status Active, not recruiting

Clinical Trial Summary

Clinical Trial Description

The purpose of this study is to determine the clinical and economic effectiveness of a pharmacogenomic (PGx) approach to prescribing medications in patients with high-risk polypharmacy in an integrated healthcare delivery system. Investigators hypothesize that patients who receive the RightMed® PGx test from OneOme, LLC with subsequent counseling of their prescribers by a study pharmacist, as needed, on the appropriateness of their prescribed medications will experience lower one-year follow-up healthcare utilization and expenditures compared to control patients who receive usual care. Primary Objectives: 1. Healthcare expenditures: 6- and 12-month changes in total healthcare expenditures from the Kaiser Permanente Colorado (KPCO) perspective 2. Healthcare utilization: 6- and 12-month changes in hospitalizations, emergency room visits, medical office visits, and telephone encounters Secondary Objectives: 1. Medication changes: Counts of 6-month medication and/or dose adjustments in targeted medications 2. Medication congruence: Description of counts of RightMed test recommendations accepted by prescribers 3. Medication adherence: 6- and 12-month changes in percent of days (PDC) covered for targeted medications 4. Pharmacy expenditures: 6- and 12-month changes in outpatient prescription medication expenditures from the KPCO perspective ;

Study Design

Related Conditions & MeSH terms

Polypharmacy

Clinical Trial Details

NCT number	NCT04120480
Study type	Interventional
Source	Kaiser Permanente
Contact
Status	Active, not recruiting
Phase	N/A
Start date	November 15, 2019
Completion date	December 31, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03688542` - Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module	N/A
Completed	`NCT02545257` - Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Care	N/A
Withdrawn	`NCT01932632` - Medication Minimization for Long-term Care Residents	N/A
Recruiting	`NCT04615065` - Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Active, not recruiting	`NCT04181879` - Appropriate Polypharmacy in Older People in Primary Care	N/A
Not yet recruiting	`NCT03283735` - Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal	N/A
Completed	`NCT02918058` - Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults	N/A
Enrolling by invitation	`NCT05656560` - Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges R01 Trial	N/A
Completed	`NCT03655405` - Randomised, Controlled Trial of an Individual Deprescribing Intervention for Nursing Homes Residents	N/A
Completed	`NCT04575155` - Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management	N/A
Withdrawn	`NCT05816967` - Rationalisation of Polypharmacy by the RASP-instrument and Discharge Counselling of Geriatric Inpatients	N/A
Completed	`NCT05616689` - Bundled Hyperpolypharmacy Deprescribing	N/A
Terminated	`NCT04055896` - Team Approach to Polypharmacy Evaluation and Reduction in a Long-Term Care Setting	N/A
Active, not recruiting	`NCT03052192` - Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
Completed	`NCT02866799` - Multi-PAP: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy	N/A
Completed	`NCT01732302` - Educational Intervention to Reduce Drug-related Hospitalizations in Elderly Primary Health Care Patients	N/A
Enrolling by invitation	`NCT05053815` - Pharmacogenomic Testing in a Program of All-inclusive Care for the Elderly (PACE) Setting
Recruiting	`NCT04585191` - Reducing Treatment Risk in Older Adults With Diabetes	N/A
Recruiting	`NCT05609981` - Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems	N/A
Recruiting	`NCT05501223` - Physician-initiated Medication Review in a Type 2 Diabetes Outpatient Clinic	N/A