Carpal Tunnel Syndrome Clinical Trial
Official title:
A Multicenter Observational Retrospective-prospective Study of Prevalence, Clinical Characteristics of Hereditary Transthyretin Amyloidosis Polyneuropathy in Russian Patients Undergoing Surgery for CTS in Real Clinical Practice
This is a multicenter observational study consisting of retrospective and prospective phases. The retrospective phase will entail secondary data collection from electronic or paper medical records of patients who underwent surgery for CTS to assess their probability of having ATTR PN.
ATTR PN is a genotypically, phenotypically and geographically variable disease with a poor prognosis, albeit available disease-modifying drugs can change the disease trajectory. Thus country-specific epidemiologic data collection and identification of early stage PN, including previously misdiagnosed patients, is crucial to improve outcomes and quality of life. However, no observational studies on the epidemiology of ATTR PN in the whole Russian population, or in patients with CTS, have been performed. Therefore, there is a need to conduct a large-scale observational study to determine the prevalence of ATTR PN in Russia, obtain information on patients' clinical characteristics, and determine their medical needs. The approaches to diagnosis of ATTR PN in Russia over the past few years have been characterized by the use of heterogenous methods, partially explained by the lack of availability of molecular genetic testing, which is essential to diagnose the presence of pathogenic mutation in patients with hereditary ATTR PN. Thus, recent introduction of such tests into routine clinical practice may allow to assess reliable epidemiologic data including estimation of true ATTR PN prevalence among patients with CTS, which can often be the first manifestation of the disease. Earlier recognition, in turn, may lead to timely treatment initiation and change in the prognostic outlook of ATTR PN patients. In order to assess the prevalence of ATTR PN in patients undergoing surgery for CTS in Russia this study will retrospectively include patients with the diagnosis of CTS undergoing surgery between the 1st January 2021 and the 1st September 2024. Suspicion of ATTR PN will be assessed in each case, and diagnostic tests (comprehensive neurological examination including nerve conduction study (NCS) combined with molecular genetic testing) to confirm or exclude the disease will be conducted prospectively in eligible patients. In addition to that, clinical features, concomitant manifestations, and diagnosed genotypes will be analyzed to examine characteristic ATTR PN patient profiles in the Russian Federation. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05067205 -
Minimal Invasive Carpal Tunnel Release With the Novel Device
|
N/A | |
| Completed |
NCT03184688 -
Platelet Rich Plasma for Carpal Tunnel Syndrome
|
N/A | |
| Completed |
NCT03582735 -
Preoperative Neuromobilization Exercises for Individuals With Carpal Tunnel Syndrome
|
N/A | |
| Completed |
NCT05490420 -
Effects of Upper Extremity Manual Lymphatic Drainage on Symptom Severity, Hand Functions, Electrophysiological and Ultrasonographic Measurements in Carpal Tunnel Syndrome
|
N/A | |
| Recruiting |
NCT05970692 -
Cross-Cultural Adaptation and Psychometric Validation of the Turkish Version of Atroshi-Lyrén 6-item Symptoms Scale
|
||
| Completed |
NCT04043780 -
Clinical Validation of a Decompression Prototype Splint for Patients With Carpal Tunel Syndrome
|
N/A | |
| Completed |
NCT03880812 -
Cost Information on Carpal Tunnel Syndrome Treatment Decisions
|
N/A | |
| Completed |
NCT06464809 -
Treatment Intervention of Patients With Carpal Tunnel Syndrome (CTS)
|
N/A | |
| Recruiting |
NCT05328180 -
aDjunct bicarbonatE in Local anaesthesIa for CarpAl Tunnel rElease (DELICATE)
|
N/A | |
| Recruiting |
NCT05503719 -
An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial
|
N/A | |
| Recruiting |
NCT05372393 -
Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block
|
N/A | |
| Recruiting |
NCT05466162 -
Soft Tissue Massage Along With Mobilization Technique on Symptoms and Functional Status of Carpal Tunnel Syndrome
|
N/A | |
| Completed |
NCT04060875 -
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
|
||
| Not yet recruiting |
NCT06294821 -
4AP to Delay Carpal Tunnel Release (CTR)
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT04328805 -
Pain Reduction and Changes in Upper Limb Function Produced by an Ibuprofen Treatment in Carpal Tunnel Syndrome.
|
Phase 4 | |
| Terminated |
NCT02791529 -
Scalpel Versus Electrocautery for Surgical Skin Incision in Open Carpal Tunnel Release
|
Phase 1 | |
| Completed |
NCT02141035 -
Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome
|
Phase 2/Phase 3 | |
| Completed |
NCT01887145 -
Comparison of Long-term Outcomes Following Endoscopic or Open Surgery for Carpal Tunnel Syndrome
|
N/A | |
| Recruiting |
NCT01897272 -
Post-Operative Splinting After Short-Incision Carpal Tunnel Release: a Prospective Study
|
N/A | |
| Completed |
NCT01394822 -
Neuromuscular Ultrasound for Focal Neuropathies
|
N/A |