Polyneuropathy Clinical Trial
Official title:
Neuromuscular Electrical Stimulation in the Critically Ill
Neuromuscular stimulation (NMES) has been used for several years in the rehabilitation of
COPD (chronic obstructive pulmonary disease) patients (among others) to improve their
resistance to efforts in everyday life. In patients in intensive care, it seems to improve
strength, reduce the loss of muscle mass, prevent the development of CIP / CIM (Critical
illness polyneuropathy / critical illness myopathy) and perhaps even reduce ventilation days,
with expected effects on the duration of hospitalization and the long-term functional
outcome. Although its use could sometimes be limited by the development of peripheral edema
and use of vasoconstrictors, the main advantage of this technique is the possibility of being
used very early, even in patients that require deep sedation . This is extremely important
given that the muscular atrophy process already starts 18h after the onset of invasive
ventilation and as signs of impaired nerve transmission are developed in one third of
patients at risk within 72 hours.
The purpose of the study is to assess the effects, in the short and medium term, of early
neuromuscular stimulation in patients who are at higher risk of developing a critical illness
polyneuropathy (CIP) / critical illness myopathy (CIM) spectrum disease.
This is a randomized controlled single-blind study comparing a group of patients submitted to
NMES early (up to 5 days after admission) versus a control group unstimulated.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05560555 -
Retrospective Study Collecting Neurological Follow-up of Hereditary Transthyretin Amyloidosis (ATTRv) Patients Included in B3461028 and B3461045.
|
||
Recruiting |
NCT02033057 -
Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
|
Phase 4 | |
Completed |
NCT02442986 -
Neurological Outcome in Surgical and Non-surgical Septic Patients
|
N/A | |
Completed |
NCT02706314 -
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
|
||
Completed |
NCT01076478 -
Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines
|
Phase 4 | |
Completed |
NCT03373370 -
Early Diagnosis of TTR Amyloidosis by Use of Molecular Biology
|
||
Completed |
NCT02846844 -
Patients With Chemotherapy-induced Polyneuropathy Are Treated With an Integrated Program Including Massage, Mobilization in Posture and Transport Layers, Physical Exercises or With Whole-body Vibration Platform Training
|
N/A | |
Recruiting |
NCT05950867 -
Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause.
|
N/A | |
Terminated |
NCT00832572 -
Study of Ranexa in Patients With Coronary Artery Disease and Painful Polyneuropathy
|
Phase 4 | |
Completed |
NCT00614562 -
Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M)
|
Phase 1 | |
Completed |
NCT01302275 -
Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain
|
Phase 4 | |
Terminated |
NCT01088256 -
Efficacy of Etoricoxib on Peripheral Hyperalgesia
|
Phase 2 | |
Not yet recruiting |
NCT01047488 -
Imipramine and Pregabalin Combination in Painful Polyneuropathy
|
Phase 4 | |
Recruiting |
NCT06414746 -
Hereditary Transthyretin Amyloidosis Polyneuropathy in Patients With Carpal Tunnel Syndrome in Russia
|
||
Completed |
NCT04201418 -
A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation
|
||
Completed |
NCT01450163 -
Evaluate The Efficacy and Safety Of Pregabalin In Prevention, Reduction of Oxaliplatin-Induced Painful Neuropathy
|
Phase 3 | |
Recruiting |
NCT05040373 -
Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
|
||
Not yet recruiting |
NCT02666456 -
The Influence of Sensory Phenotype on the Risk of Developing Neuropathic Pain
|
N/A | |
Withdrawn |
NCT00723918 -
Combination of an Investigational Cannabinoid and Methadone for HIV-associated Neuropathy
|
Phase 2 | |
Completed |
NCT00259974 -
RIMAG Study: Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy
|
Phase 3 |