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Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause.

Amyloidosis Clinical Trial

Official title:
Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause: a Prospective Monocentric Study (CAP-TTR)

Clinical Trial Summary

To investigate to what extent chronic axonal length-dependent polyneuropathy (CAP) and/or small-fiber neuropathy (SFN) is part of early non-cardiac manifestations of wild-type TTR cardiac amyloidosis (wtTTR-CA). Consequently, explore whether this could ultimately lead to faster diagnosis and clinical outcome of wild-type TTR cardiac amyloidosis (wtTTR-CA).

Clinical Trial Description

Patients with chronic axonal length-dependent polyneuropathy (CAP) and/or small-fiber neuropathy (SFN) without well-defined cause will be recruited after a neurological standard routine work-up with NCS (Nerve conduction study) test, EMG, and Sudoscan®, previously performed at the neurology department of UZ-Brussel in normal clinical setting. All participants will be invited to the Neurology and Cardiology department for one visit on one day, for the following assessments: Following exams will be performed: - assessment of symptoms, severity, and duration of the polyneuropathy and the use of NTSS-6 and COMPASS31 score for mapping somatosensory and autonomic symptoms - evaluation of objective polyneuropathy signs, using following scales: mPND, NIS - Kansas City Cardiomyopathy Questionnaire (KCCQ) - Electrocardiogram (ECG) - Echocardiography The following retrospective data from the medical file will be analyzed: - assessment of medical history, medical treatment, and demographic data - assessment of laboratory results (and, if applicable, other exams) extracted from the medical file and previously performed in the context of polyneuropathy workup - assessment of previously performed NCV/EMG data and Sudoscan®, extracted from the medical file of the participants. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05950867
Study type Interventional
Source Universitair Ziekenhuis Brussel
Contact Véronique Bissay, MD,Phd
Phone +32 2 477 68 01
Email veronique.bissay@uzbrussel.be
Status Recruiting
Phase N/A
Start date July 28, 2023
Completion date June 1, 2026
View Details
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