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Clinical Trial Summary

The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.


Clinical Trial Description

We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort. ;


Study Design

Observational Model: Case Control, Time Perspective: Longitudinal


Related Conditions & MeSH terms


NCT number NCT00155103
Study type Observational
Source National Taiwan University Hospital
Contact Li-Hui Tseng, M.D., Ph.D.
Phone +886-2-2312-3456
Email htseng@ha.mc.ntu.edu.tw
Status Recruiting
Phase N/A
Start date August 2004

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