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Polyethylene Glycol clinical trials

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NCT ID: NCT05726344 Completed - Colonoscopy Clinical Trials

Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults

Start date: February 10, 2023
Phase: N/A
Study type: Interventional

Colonoscopy is the gold standard in bowel assessment when there is suspicion of colon and rectum pathology. Bowel cleansing is necessary to ensure an optimal visualization of colonic mucosa, allowing this form of detection and removal of polyps. Nowadays international recommendations have multiple bowel preparations. There are differences among them regarding adherence, tolerance and adverse effects. Lactulose (LAC) is widely used in treating constipation. However, there are some randomized clinical assays using LAC as bowel preparation with excellent results according to bowel preparation and tolerance scales. Adherence to bowel preparation significantly affects the result in the endoscopic study. Safety of polyethylene glycol (PEG) formulations has been validated in several studies, it presents little severe side effects and the advantage of its applicability to patients with several comorbidities (heart, liver and kidney without water deprivation). However, its main disadvantage lies in the need to ingest large amounts of liquid (3-4L), generating intolerance thereto in 15%-45% of patients. Bowel cleansing preparation with PEG is widely used in clinical practice. Considering that according to international studies reporting better tolerance and adherence with LAC; it is suggested to compare the level of bowel preparation, tolerance and adherence between two groups with LAC and PEG.

NCT ID: NCT04290715 Completed - Colonoscopy Clinical Trials

Development and Validation for Predicting Inadequate Bowel Preparation

Start date: January 1, 2020
Phase:
Study type: Observational

High-quality colonoscopy is considered the gold standard for the detection and prevention of colorectal cancer, and its efficacy is predicated on optimal colon cleansing.However, about 18%-35% of patients were still reported to suffer inadequate bowel preparation. Although several predictive models exist, the current guideline indicates that there is insufficient evidence to recommend the use of a predictive model for clinical practice.

NCT ID: NCT03817788 Completed - Polyethylene Glycol Clinical Trials

Randomized Controlled Trail of Polyethylene Glycol vs Sodium Phosphate for Colonic Cleansing of Colonoscopy

Start date: April 26, 2019
Phase: Phase 4
Study type: Interventional

This study is to compare polyethylene glycol and sodium phosphate for colonic cleansing of colonoscopy.