Glucose Metabolism in Different PCOS Phenotypes

Polycystic Ovary Syndrome Clinical Trial

Official title:

Associatons of PCOS Phenotypes With Ectopic Lipids, Adipocytokines and Parameters of Insulin Resistance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03204461
• Other study ID #: PCOS-1090
• Status: Completed
• Phase: N/A
• First received: June 26, 2017
• Last updated: June 27, 2017
• Start date: December 3, 2012
• Est. completion date: July 30, 2015

Study information

• Verified date: June 2017
• Source: Medical University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.

Description:

In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 73
• Est. completion date: July 30, 2015
• Est. primary completion date: July 9, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria

• healthy control subjects

Exclusion Criteria:

• BMI>=40kg/m²

• Diagnosis of Diabetes in the PCOS-Group

• Diagnosis of Prediabetes or Diabetes in the control group

Related Conditions & MeSH terms

• Glucose Intolerance
• Glucose Metabolism Disorders
• Liver Fat
• Metabolic Diseases
• Polycystic Ovary Syndrome

Intervention

Diagnostic Test:
• Oral glucose tolerance test (OGTT)
For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.

Other:
• 1H-magnetic resonance spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.

Locations

Country	Name	City	State
Austria	Medical University of Vienna	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT.	In the present study the Glucose metabolism in PCOS women and control subjects was assessed with an OGTT. Therefore the dynamic levels of glucose, insulin and C-peptide were assessed during an extended OGTT for the calculation of Insulin resistance and beta-cell function. In addition an 1H-magnetic resonance spectroscopy was done for the assessment of the ectopic lipid content in the liver, heart and the skeletal muscle.	Up to 4 weeks