Polycystic Ovary Syndrome Clinical Trial
Official title:
Oxidative Stress and BPA Impact With PCOS
Both oxidative stress and Bisphenol A (BPA) had been associated with polycystic ovary
syndrome (PCOS). BPA, one of endocrine-disrupting chemicals (EDCs), is an environmental
estrogen used in the synthesis of plastics, is a "high-volume production" chemical with
widespread human exposure. BPA was been reported in several female reproductive disturbance.
However, the pathological pathway of BPA impact on female reproductive system had not been
well-understood. Reactive oxygen species (ROS) have a role in the modulation of gamete
quality and gamete interaction. Persistent and elevated generation of ROS leads to a
disturbance of redox potential that in turn causes oxidative stress (OS). The first part of
The investigators study is aim to evaluate the oxidative stress impact on the biochemical
parameters in women with PCOS; the secondary part of the investigators study is to
investigate the BPA on the clinical and biochemical of women with PCOS; finally, the
investigators plan to test the hypothesis that BPA might increase oxidative stress and then
elevated ROS in women with menstrual disturbance, furthermore, the role of oxidative stress
and BPA impact on insulin resistance and metabolic disturbance will be also investigated.
Study and control cases will be included. Serum total oxidant status (TOS), total
antioxidant status (TAS), Bisphenol A (BPA), and clinical/biochemical parameters will be
obtained for all cases. Oxidative stress and BPA will be evaluated with all
clinical/biochemical parameters for all subjects.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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