Polycystic Ovarian Syndrome Clinical Trial
Official title:
The Effect Of Cabergoline On Follicular Microenvironment Profile In Patients With High Risk Of Ohss
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I), antimullerian hormone (AMH), inhibin B and hepatocyte growth factor (HGF) levels in women with PCOS and high risk of ovarian hyperstimulation syndrome (OHSS).
Status | Completed |
Enrollment | 40 |
Est. completion date | March 2009 |
Est. primary completion date | March 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 23 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Development of more than 14 leading follicles larger than 10 mm and serum estradiol more than 3000 pg/ml at the end of ovulation induction with long luteal ovulation induction protocol. - Having the criteria of PCOS Exclusion Criteria: - Not having the inclusion criteria. |
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Etlik Zubeyde Hanim Womens' Health and Teaching Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Concentrations of follicular fluid AMH | 1 year | No | |
Secondary | Concentrations of follicular fluid inhibin B | 1 year | No | |
Secondary | Concentrations of follicular fluid HGF | 1 year | No |
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