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PBPK Modelling Applied to Acetaminophen Poisoned Obese Children — IntoxPara  

Obesity Clinical Trial

Official title:
Physiologically-based Pharmacokinetic Modelling Applied to Acetaminophen- Poisoned Obese Children

Clinical Trial Summary

Childhood obesity is increasing globally. Changes in body composition and physiology in obesity setting modify pharmacokinetic parameters and might increase the risk in case of poisoning. Acetaminophen is a drug often implied in poisoning in children population, especially in adolescent attempting suicide. In practice, clinicians use weight to assess intoxication severity, but depending on the weight chosen (actual weight, lean body weight, ideal weight,..) the severity assessment can change as well as medical care needed. In this context we hypothesize that a PBPK modelling would be helpful to predict toxic dosing in obese population and especially in obese adolescent or children. The primary objective of this study is to collect data related to acetaminophen-poisoned patient with at least one acetaminophen concentration sampling and whose clinical outcome is known in order to refine and validate such a PBPK model.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04850014
Study type Observational
Source Hospices Civils de Lyon
Contact Kim An NGUYEN, MD
Phone 4 72 31 94 11
Email kim-an.nguyen@chu-lyon.fr
Status Recruiting
Phase
Start date January 1, 2021
Completion date October 2021
View Details
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