Study of the Disease Process of Lymphangioleiomyomatosis

Status Recruiting

Clinical Trial Summary

Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor. This study is designed to determine the disease processes involved at the level of cells and molecules, in order to develop more effective therapy. Researchers intend to identify the proteins and genes that contribute to the process of lung destruction in affected individuals. ...

Clinical Trial Description

Individuals with pulmonary lymphangioleiomyomatosis develop severe destructive lung disease. Most of them are females of childbearing age. Currently, there is no proven effective therapy and the prognosis is variable. This study is designed to (a) define the clinical course of the disease and (b) elucidate the pathogenesis of the disease at the cellular and molecular levels, in order to develop more effective therapy. To accomplish this, we intend to identify the proteins and genes that contribute to the process of lung destruction in affected individuals. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00001465
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact	Tatyana Worthy, R.N.
Phone	(301) 827-1376
Email	worthyt@mail.nih.gov
Status	Recruiting
Phase
Start date	December 18, 1995

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06022081` - Lung Ultrasound Versus Chest Radiography for Detection of Pneumothorax	N/A
Recruiting	`NCT02907866` - Use of Endobronchial Ultrasound Scope (EBUS) Transducer to Identify Pneumothorax-A Feasibility Study
Terminated	`NCT03034421` - Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema	N/A
Completed	`NCT02232841` - Electrical Impedance Imaging of Patients on Mechanical Ventilation	N/A
Completed	`NCT02619591` - Comparison Of Chest Ultrasound Techniques To Identify Clinically Significant Pneumothorax	N/A
Recruiting	`NCT05342675` - Effect of Rapid Rollover on Pneumothorax After CT-Guided Lung Biopsy	N/A
Recruiting	`NCT05910112` - Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
Completed	`NCT03656406` - Effect of Lateral Positioning on Bronchial Cuff Pressure of Left-sided Double-lumen Endotracheal Tube During Thoracic Surgery
Active, not recruiting	`NCT06075836` - AI Assisted Detection of Chest X-Rays
Recruiting	`NCT03728491` - Education and Training Competences in Thoracic Ultrasound	N/A
Recruiting	`NCT05407974` - Pleurectomy Versus Pleural Abrasion in Patients With Spontaneous Pneumothorax	N/A
Completed	`NCT01670942` - Hypobaria and Traumatic Pneumothorax	N/A
Terminated	`NCT00969423` - Chronic Pain After Video-assisted Thoracoscopic Surgery (VATS) Surgery for Pneumothorax	N/A
Completed	`NCT05904574` - Effectiveness of the Autologous Blood Patch Method in Lung Biopsies
Completed	`NCT03327688` - Point-of-care Ultrasound in Finland	N/A
Completed	`NCT05963945` - Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
Completed	`NCT05222568` - Effect of the Minimum Bronchial Cuff Volume of Left-sided Double-lumen Endotracheal Tube for One-lung Ventilation on the Change of the Bronchial Cuff Pressure During Lateral Positioning in Thoracic Surgery
Not yet recruiting	`NCT05121233` - Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures	Phase 4
Completed	`NCT03064659` - Driving Pressure And EFL in Adult Cardiac Surgery	N/A
Recruiting	`NCT02090205` - Mechanical Ventilation During Cardiac Surgery	N/A