Study of the Disease Process of Lymphangioleiomyomatosis

Status Recruiting

Clinical Trial Summary

Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor. This study is designed to determine the disease processes involved at the level of cells and molecules, in order to develop more effective therapy. Researchers intend to identify the proteins and genes that contribute to the process of lung destruction in affected individuals.

Clinical Trial Description

Individuals with pulmonary lymphangioleiomyomatosis develop severe destructive lung disease. Most of them are females of childbearing age. Currently, there is no proven effective therapy and the prognosis is variable. This study is designed to (a) define the clinical course of the disease and (b) elucidate the pathogenesis of the disease at the cellular and molecular levels, in order to develop more effective therapy. To accomplish this, we intend to identify the proteins and genes that contribute to the process of lung destruction in affected individuals. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00001465
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact	Tatyana Worthy, R.N.
Phone	(301) 827-1376
Email	worthyt@mail.nih.gov
Status	Recruiting
Phase
Start date	December 18, 1995

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