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NCT06246994 Clinical Trial

Predictors of Mortality Among Ventilator Associated Pneumonia Patients

Pneumonia Clinical Trial

Official title:
Predictors of Mortality Among Ventilator Associated Pneumonia Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06246994
Other study ID # Predictors of vap mortality
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date March 2024
Est. completion date September 2025

Study information
Verified date February 2024
Source Assiut University
Contact Marwa Kilany, Assisst- lecture
Phone 01064123545
Email docmero1693@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In this context, this study aims to explore the risk factors for mortality from VAP in respiratory ICU.

Description:

Pneumonia is the most common infection treated within ICUs and carries significant mortality risk . Ventilator-associated pneumonia (VAP) is a specific form of nosocomial pneumonia occurring in patients greater than 48 hours after intubation and the initiation of mechanical ventilation . VAP is considered a leading cause of morbidity and mortality among intensive care unit infections. Despite various preventive measures, the incidence of VAP remains high . In studies, VAP-related mortality is 14-70% . It is contemplated that there are independent risk factors, increasing VAP-related mortality . However, the question of which factors are associated with early or late mortality in patients with VAP diagnosis, remains unanswered. Early identification and understanding of the etiology of VAP in the ICU is essential to prevent mortality and morbidity.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 140
Est. completion date September 2025
Est. primary completion date March 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:This study will enroll: 1. adult participants over 18 years old who had undergone mechanical ventilation for longer than 48 hours. 2. Only the first episode of VAP for each patient will be included. Exclusion Criteria: 1. Patients who are less than 18 years old. 2. Pneumonia diagnosed before mechanical ventilation.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

References & Publications (5)

Arayasukawat P, So-Ngern A, Reechaipichitkul W, Chumpangern W, Arunsurat I, Ratanawatkul P, Chuennok W. Microorganisms and clinical outcomes of early- and late-onset ventilator-associated pneumonia at Srinagarind Hospital, a tertiary center in Northeaster — View Citation

John AO, Paul H, Vijayakumar S, Anandan S, Sudarsan T, Abraham OC, Balaji V. Mortality from acinetobacter infections as compared to other infections among critically ill patients in South India: A prospective cohort study. Indian J Med Microbiol. 2020 Jan — View Citation

Vincent JL, Sakr Y, Singer M, Martin-Loeches I, Machado FR, Marshall JC, Finfer S, Pelosi P, Brazzi L, Aditianingsih D, Timsit JF, Du B, Wittebole X, Maca J, Kannan S, Gorordo-Delsol LA, De Waele JJ, Mehta Y, Bonten MJM, Khanna AK, Kollef M, Human M, Angu — View Citation

Zhou XY, Ben SQ, Chen HL, Ni SS. A comparison of APACHE II and CPIS scores for the prediction of 30-day mortality in patients with ventilator-associated pneumonia. Int J Infect Dis. 2015 Jan;30:144-7. doi: 10.1016/j.ijid.2014.11.005. Epub 2014 Nov 12. — View Citation

Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL. Intensive care unit length of stay: Benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med. 2006 Oct;34(10):2517-29. doi: 10.1097/01.CCM.0000240233.01711.D — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Mortality rate at 28 days. Evaluation of number of dead patients from vap wihin 28 days of infection and 28 days
Primary Percentage of risk factors of VAP mortality. Search for risk factors for mortality of vap wihin 28 days of infection. 28 days
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