Pneumonia Clinical Trial
— STREPTOOfficial title:
A 20-months Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium to Evaluate National Vaccination Strategy
The investigators will conduct a prospective observational study of non-invasive S. pneumoniae infections in Belgium and characterize serotype distributions to evaluate national vaccination programs.
Status | Recruiting |
Enrollment | 3600 |
Est. completion date | December 31, 2025 |
Est. primary completion date | May 1, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Patients living in Belgium at the time of the study, - from whom unduplicated S. pneumoniae isolates were collected in routine practices, - from non-invasive upper (e.g.: pus/fluid from nasal sinus or from otitis media fluid) or lower respiratory tract (e.g. sputum bronchial or endotracheal aspirate, bronchoalveolar fluid (BAL),…) clinical samples, - from patients diagnosed with pneumonia, sinusitis and otitis. Exclusion Criteria: • Patients for whom S. pneumoniae was simultaneously isolated from blood or another usually sterile specimen |
Country | Name | City | State |
---|---|---|---|
Belgium | Sciensano | Brussels |
Lead Sponsor | Collaborator |
---|---|
Sciensano | Merck Sharp & Dohme LLC, Pfizer, Universitaire Ziekenhuizen KU Leuven |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Establish insight in serotype dynamics for non-invasive pneumococcal diseases in Belgium prospectively, in association with changing vaccination programs (campaigns). | There is a wealth of information available on the serotype distribution of S. pneumoniae causing inavsive pneumococcal disease (IPD). However, much less is known about the serotype distribution of S. pneumoniae causing non-invasive pneumococcal disease (NIPD). The goal of this study is to characterize the serotype distribution of of S. pneumoniae causing NIPD in Belgium, compare is with IPD data and link it with the changing national vaccinations programs. | September 2020-May 2025 | |
Secondary | Surveillance of emerging serotypes, clones and drug resistances. Study of the genetic divergences between invasive and non-invasive pneumococcal diseases isolates. | To date, little is known about serotype distribution in NIPD and how this relate with the more widely studied serotype distribution in IPD. This study aims to shed light onto this topic. | September 2020-May 2025 |
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