Pneumonia Clinical Trial
Official title:
Effects of Immunonutrition on the Acute Immune Response in Hospitalized Patients With Pneumonia
The project is a randomized controlled trial taking place in the North Zealand hospital in
the city Hilleroed, Denmark.
The aim is to investigate the potential beneficial effects of immunonutrition containing fish
oil, arginine and RNA, on the acute immune response in patients with pneumonia.
Immunonutrition has a well-documented beneficial effect on surgical patients by strengthening
the immune system and reducing the following: inflammation, the number of infections as well
as hospitalization time. A study in operated patients demonstrated the benefit of
immunonutrition by reducing unwanted inflammation, measured by the pro-inflammatory
signalling protein, interleukin-6. The same study saw a smaller decrease in immune function
(measured as the level of phagocytosis) in the group receiving immunonutrition than in the
control group. This project will investigate whether similar effects can be detected in
patients with pneumonia.
The project is being carried out in a collaboration between the University of Copenhagen, The
main hospital of Copenhagen (Rigshospitalet) and North Zealand Hospital. The project is a
randomized clinical intervention study, which spans 10 days. Participants are allocated to
the intervention group or the control group. The project is being carried out at the North
Zealand hospital, at the Department of Pulmonary- and Infectious Diseases.
The intervention group receives the department's standard treatment (Standard Of Care) +
immunonutrition, while the control group receives the hospital department's standard
treatment (Standard Of Care). On a daily basis, the patient's clinical condition and the
activity of the immune system is measured for the purpose of determine whether there is an
effect of immunonutrition.
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