Pneumonia Clinical Trial
Official title:
An Open-label, Randomized, and Comparative Study to Evaluate the Efficacy and Safety of Cefoperazone/Sulbactam in Comparison to Cefepime for the Treatment of Hospital-acquired Pneumonia and Healthcare-associated Pneumonia
This is a phase III, multi-center, open-label, comparative and randomized study in evaluating the efficacy and safety of cefoperazone/sulbactam versus cefepime for the treatment of hospital-acquired pneumonia and healthcare-associated pneumonia. The investigator will determine the total duration of study therapy, as clinically indicated. The minimum duration of study therapy will be 7 days and the maximum allowable duration of study therapy will be 21 days.
Patients fulfill inclusion/exclusion criteria will be randomly assigned (in a 1:1 ratio)to
receive intravenous cefoperazone/sulbactam or intravenous cefepime for 7~21days. Vitamin K1
10mg will be administered to cefoperazone/sulbactam group every 24 hours.
The assessment of clinical sign and symptoms of pneumonia and microbiological tests will be
performed at early post-therapy visit and test-of-cure visit.
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Observational Model: Cohort
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