Pneumonia Clinical Trial
Official title:
Effect of the Association of a Statin to Antibiotics on the Prognosis of Patients Presenting With a Suspicion of Ventilator-associated Pneumonia
The objective is to assess the efficacy and safety of oral simvastatin in patients with a suspicion of ventilator-associated pneumonia (VAP). The hypothesis of this study is that simvastatin therapy will improve mortality in patients a suspicion of VAP.
When a patient will present a suspicion of VAP (Clinical Pulmonary Infection Score modified
≥ 5), Simvastatin or placebo will be administered with antibiotics. Quantitative cultures
will be performed for microbiological confirmation of VAP. Simvastatin or placebo will be
administered through an enteral feeding tube or administered orally when patients are able
to safely take oral medications. The type and placement of the enteral feeding tube
(nasogastric, nasoenteric, PEG, orogastric, oroenteric, etc.) and the ability to safely take
oral medications will be determined by the patient's primary team. Study drug will be
blinded with an identical appearing placebo.
Sequential Organ Failure Assessment score (SOFA), and various blood factors will be measured
during treatment.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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