Clinical Trials Logo
  1. Home
  2. Pneumonia
  3. NCT00841074
  4. Details
NCT00841074 Clinical Trial

Chlorhexidine & Pneumonia in Nursing Home Residents

Pneumonia Clinical Trial

Official title:
Effect of Topical Oral Chlorhexidine in Reducing Pneumonia in Nursing Home Residents

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00841074
Other study ID # OGMB040944
Secondary ID DE015760
Status Completed
Phase Phase 1
First received February 9, 2009
Last updated April 12, 2017
Start date January 2006
Est. completion date July 2011

Study information
Verified date December 2016
Source University of Louisville
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is determine if topical oral application of a chlorhexidine antimicrobial spray will significantly reduce pneumonia and respiratory infections, and improve oral health compared to a placebo solution in nursing home residents.

Recruitment information / eligibility
Status Completed
Enrollment 75
Est. completion date July 2011
Est. primary completion date July 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 65 Years and older
Eligibility Inclusion Criteria:

1. Participants must be at least 65 years old.

2. Be dependent in 2 or more Activities of Daily Living as noted on the nursing home resident's Minimum Data Set - One must be ADL J- Personal Hygiene.

3. Have natural teeth and/or wear complete or partial dentures.

4. Expected to be a resident in a nursing home for two years.

Exclusion Criteria:

1. Existing pneumonia.

2. History of chlorhexidine reaction or allergy and/or multiple medication or substance allergies.

3. Receiving chlorhexidine oral application at enrollment as prescribed by physician or dentist.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• chlorhexidine
0.12% chlorhexidine mouthwash spray, ~1.3 ml, twice a day.
• Placebo mouthwash
Placebo mouthwash spray application of ~1.3 ml twice a day.

Locations
Country Name City State
United States University of Louisville Louisville Kentucky

Sponsors (2)
Lead Sponsor Collaborator
University of Louisville National Institute of Dental and Craniofacial Research (NIDCR)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Pneumonia 12 months
Secondary Respiratory pathogens 12 months
Secondary Plaque and Gingival Indices 12 months
See also
  Status Clinical Trial Phase
Active, not recruiting NCT04244474 - Effect of Vitamin D Supplementation on Improvement of Pneumonic Children Phase 1/Phase 2
Completed NCT05815264 - Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Chinese Population Aged 2 Years and Above Phase 1
Recruiting NCT04589936 - Prone Position to Improve Oxygenation in COVID-19 Patients Outside Critical Care N/A
Completed NCT02905383 - The Effect of Exercise on Physical Function and Health in Older People After Discharge From Hospital N/A
Terminated NCT03944551 - Bubble Continuous Positive Airway Pressure for Children With Severe Pneumonia in Mali, Africa N/A
Completed NCT06210737 - A Study to Evaluate Persistence of Immunity of PCV13 in Healthy Population Aged 2 Months，7 Months-5 Years Phase 4
Terminated NCT04660084 - Impact of Molecular Testing on Improved Diagnosis, Treatment and Management of CAP N/A
Not yet recruiting NCT05649891 - Checklists Resuscitation Emergency Department N/A
Withdrawn NCT05702788 - Efficacy and Safety of Jaktinib in Participants With Severe Novel Coronavirus Pneumonia(COVID-19) Phase 2
Not yet recruiting NCT04171674 - Pharmacokinetics of High-dose Ceftobiprole in Community-acquired Pneumonia Under Mechanical Ventilation. N/A
Active, not recruiting NCT03140163 - Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT [ULD-CT] and Conventional Chest Radiography [CXR] N/A
Completed NCT02864420 - Hospitalization at Home: The Acute Care Home Hospital Program for Adults N/A
Completed NCT02638649 - Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
Recruiting NCT02515565 - Physiotherapy in Patients Hospitalized Due to Pneumonia. N/A
Completed NCT02105298 - Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study) N/A
Completed NCT01446926 - Study of Investigational Pneumococcal Vaccine in Healthy Adults, Toddlers and Infants Phase 1
Completed NCT01416519 - Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation N/A
Completed NCT01399723 - Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia Phase 3
Completed NCT01476995 - Prognostic Indicators as Provided by the EPIC ClearView N/A
Terminated NCT02358642 - Drug to Prevent Pneumonia in the Tube Fed Phase 4