Pneumonia Clinical Trial
Official title:
Identification of Bacterial Species and Their Antibiotic-Resistant Spectrum in Sputum Specimen From the Patients With Pneumonia Via Nuclear Acid Detection Assay
Pneumonia is a common cause of morbidity and mortality. The diagnosis of pneumonia from the microbiology perspective has been challenging. Recent reports suggest the utility of nuclear acid detection for rapid and accurate diagnoses of these pathogens and their antibiotic-resistant spectrum. Extracted bacterial nucleic acid in sputum specimen will be identified by Nuclear acid detection assay kit with Microfluidic Pumping Chip and LAMP methods
Sputum specimens normally collected from the patients with pneumonia for routine
microbiologic testing and extra specimens will be evaluated via nuclear acid assay developed
in our laboratory. The assay will be directed at variety of both pathogens, including
Streptococcus pneumoniae, Hemophilus influenzae, Klebsiella pneumoniae, Staphylococcus
aureus, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma pneumonia, Chlamydia pneumoniae
and Legionella pneumophila, and common antibiotic-resistant genes, such as ESBLs genes,
MecA, OprD. The ultimate goal is to have an available panel of highly accurate and rapid
(same day) assay, which will be carried out in several hours for identification.
The extracted pathogen nucleic acid in sputum specimen will be identified by Nuclear acid
detection assay with Microfluidic Pumping Chip and LAMP methods. The species of bacteria and
their antibiotic-resistant gene to be detected are as listed above. As nucleic acid extracts
will be archived, other pathogens can be investigated in the future if the correlated assay
is developed. All results obtained by nuclear acid detection will be compared to results for
conventional testing as listed above. Sensitivity, specificity and predictive values will be
calculated. In cases where discordant results occur, additional testing and or medical
history review will be properly conducted.
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Observational Model: Cohort, Time Perspective: Prospective
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