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Low Dose Pulmonary Irradiation in Patients With COVID-19 Infection of Bad Prognosis — COVRTE-19  

COVID Clinical Trial

Official title:
Phase II Study of Low Dose Pulmonary Irradiation in Patients With COVID-19 Infection of Bad Prognosis

Clinical Trial Summary

The administration of low-dose lung irradiation produces anti-inflammatory effects that will decrease the pulmonary inflammatory response. The present study will evaluate the efficacy of treatment with low-dose pulmonary radiotherapy added to standard support therapy, in hospitalized patients with respiratory symptoms due to COVID-19 pneumonia, who do not experience improvement with conventional medical therapy and are not subsidiaries of ICU

Clinical Trial Description

The WHO has officially confirmed that: "Currently, there is no specific pharmacological available treatment for COVID-19". Beyond vital support, there are not currently treatment options for Coronavirus disease (COVID-19) and related pneumonia, the infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Pulmonary irradiation is an option for the treatment of COVID-19 pneumonia and could be available quickly and with a duration of about 15 minutes of treatment. Thoracic irradiation therapy at very low doses (0.5-1.0 Gy) dates back to the 1920s and was the only effective mean to treat certain infectious and inflammatory diseases prior to the development of antimicrobial therapies in the 1940s. The goal is to replicate low-dose radiation therapy, just as it was used 80 years ago for viral pneumonia with great success. It will be administered for a new disease, pneumonia caused by COVID-19, for which there is no cure and many people are dying, mainly from severe acute respiratory syndrome leading to very severe hypoxemic acute respiratory failure refractory to treatment. This therapy is expected to remedy acute respiratory syndrome by reducing inflammation, and it also has a low risk of side effects and toxicities, given the low doses received, more than one hundred times lower, compared to the usual radiotherapy used to tumor treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04414293
Study type Interventional
Source Hospital Provincial de Castellon
Contact Francisco Garcia Piñón, MSc
Phone 964354458
Email francisco.garpi@hospitalprovincial.es
Status Recruiting
Phase N/A
Start date October 1, 2020
Completion date December 31, 2021
View Details
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