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Fluid Agitation Microbiologic Yield In Pleural Infection Feasibility Study — FLAG-PINS  

Pleural Infection Clinical Trial

Official title:
Pleural Fluid Agitation For Improving The Microbiologic Diagnostic Yield In Pleural Infection - A Comparative Feasibility Study

Clinical Trial Summary

The goal of this study is to compare the microbiologic diagnostic yield of pre-aspiration agitated pleural fluid versus that of conventionally aspirated fluid in pleural infection patients. The main question it aims to answer is, whether fluid agitation helps to increase the microbiological yield.

Clinical Trial Description

In pleural infection, It is suggested that the bacteria being diagnostically targeted, might more likely be residing on the pleural surface with a better blood supply and nutrition rather than being planktonic in the acidic, glucose deficient pleural fluid. The investigators thus hypothesize that an agitation of the pleural fluid prior to sample aspiration would aid in achieving a better cellular representation of the pleural space. This could have the effect of washing bacterial cells off the pleural surface as well as moving sedimented cells in the aspirated sample. This study aims to investigate whether an increase in the microbiological yield for infected pleural fluid could be achieved by a pre-aspiration agitation of the pleural fluid which would have a positive effect on management and eventual patient outcomes. Adult participants with pleural infection will undergo thoracentesis via both the standard and agitated fluid techniques guided by thoracic ultrasound. Microbiological yields will be compared. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05702580
Study type Interventional
Source Alexandria University
Contact Ahmed S Sadaka, PhD
Phone +201005433152
Email ahmad.sadaka@alexmed.edu.eg
Status Recruiting
Phase N/A
Start date December 15, 2022
Completion date August 2023
View Details
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