Platelet Rich Plasma for Knee Osteoarthritis

Status Completed

Clinical Trial Summary

This study aimed to analyze the effect of platelet-rich plasma (PRP) on knee osteoarthritis. Eligible patients will undertake arthroscopic knee surgery plus intraoperative PRP and also receive second look surgery and intraoperative biopsy.

Clinical Trial Description

Osteoarthritis is a chronic disease defined by progressive degradation of the joint as well as loss of cartilage on joint surfaces. The degeneration that occurs in the joint leads to changes in the catabolic and anabolic activity of chondrocytes. Osteoarthritis may induce pain, stiffness and limitation in range of motion of the joint and also may impact the quality of life. Platelet-rich plasma (PRP) is a fraction of plasma that contains platelets and multiple growth factors concentrated at high level. Because activated platelets have the potential to release growth factors, PRP has been clinically used to accelerate wound healing and tissue regeneration in orthopedic and oral surgery. Although several studies have assessed the effects of PRP on knee osteoarthritis, a higher level of evidence has not been provided. This study aimed to analyze the effect of PRP on knee osteoarthritis. After performing arthroscopic knee surgery plus intraoperative PRP in eligible patients, a second look arthroscopic surgery with intraoperative biopsy will be arranged 6 months later. Pre- and post-operative imaging and clinical outcomes will also be compared. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03197441
Study type	Interventional
Source	Show Chwan Memorial Hospital
Contact
Status	Completed
Phase	N/A
Start date	August 29, 2016
Completion date	June 28, 2018

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04040985` - Legion Primary Safety and Efficacy	N/A
Active, not recruiting	`NCT04525950` - Robotized Navigation Compared to Conventional Technique in Total Knee Replacement	N/A
Recruiting	`NCT04320914` - High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis	N/A
Completed	`NCT03886142` - Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis	N/A
Terminated	`NCT04072055` - MOTO Post-marketing Surveillance Study
Not yet recruiting	`NCT05290818` - Total Versus Robotic Assisted Unicompartmental Knee Replacement	N/A
Withdrawn	`NCT03271229` - Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee	Phase 2
Recruiting	`NCT05505552` - Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:	N/A
Recruiting	`NCT05992038` - Use of a Putty as Gap Filler in Open-wedge Osteotomy	N/A
Recruiting	`NCT06066684` - Pain Phenotyping in Knee OA: a Pilot Trial
Completed	`NCT03847324` - Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty	N/A
Recruiting	`NCT05126485` - Biofeedback Retention in Individuals With AKA	Early Phase 1
Completed	`NCT04956393` - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study	N/A
Recruiting	`NCT04541342` - Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy	N/A
Completed	`NCT04391842` - Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis	Phase 1
Completed	`NCT03680807` - Power Production in Older Adults With Knee Osteoarthritis
Completed	`NCT03783455` - Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis	N/A
Recruiting	`NCT06264362` - Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia	N/A
Completed	`NCT05089253` - Effect of Physical Therapy Modalities in Osteoarthritis	N/A
Completed	`NCT04536519` - Foot Wear Modification Along With Physical Therapy in Knee Osteoarthritis	N/A