Clinical Trials Logo
  1. Home
  2. Platelet Dysfunction
  3. NCT04554901
  4. Details
NCT04554901 Clinical Trial

The Effect of Cocoa on Platelet Function Profiles in Patients

Platelet Dysfunction Clinical Trial

— ECLAIR  

Official title:
The Effect of Cocoa on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago: The ECLAIR Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04554901
Other study ID # CREC-SA.0351/05/2020
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 1, 2020
Est. completion date June 30, 2022

Study information
Verified date August 2023
Source The University of The West Indies
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not white chocolate).

Description:

Epidemiologic studies have shown inverse associations between dietary polyphenols (present in dark chocolate and cocoa) and mortality from coronary heart disease. However, the basis for this protective association is uncertain. Food polyphenols such as in cocoa reportedly have antioxidant properties and decrease platelet function in vitro. The goal of the present study was to investigate whether the beneficial antioxidant effect of polyphenol-rich cocoa can induce an improvement of endothelial and platelet function in patients with stable coronary artery disease with known platelet hyperreactivity.

Recruitment information / eligibility
Status Completed
Enrollment 25
Est. completion date June 30, 2022
Est. primary completion date June 30, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. Patients with stable coronary artery disease. 2. Patients > 18y of age. Exclusion Criteria: 1. Patients with T2DM. 2. Patients who already ingest any cocoa-based products.

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Cocoa
2-week, once-daily 70%, 50g cocoa bar manufactured by The UWI Cocoa Research Institute (14 bars)

Locations
Country Name City State
Trinidad and Tobago The University of the West Indies Saint Augustine North

Sponsors (1)
Lead Sponsor Collaborator
The University of The West Indies

Country where clinical trial is conducted

Trinidad and Tobago, 

Outcome
Type Measure Description Time frame Safety issue
Primary P2Y12 Reaction Units P2Y12 Reaction Units pre- and post-Cocoa 2-weeks
See also
  Status Clinical Trial Phase
Completed NCT03621020 - Clinical Performance Evaluation of T-TAS 01 PL Chip
Completed NCT03667066 - clOpidogrel "resIstaNce" in a Selected Population of Patients at a Tertiary Cardiovascular Center in Trinidad
Recruiting NCT05588011 - Influence of Oxygenator Selection on Platelet Function and Rotational Thromboelastometry Following Cardiopulmonary Bypass N/A
Completed NCT01454427 - Influence of Anesthesia Drugs on Impedance Aggregometry N/A
Completed NCT03188705 - CES1 Carriers in the PAPI Study Phase 4
Recruiting NCT03583229 - Coronary Artery Disease After Heart Transplantation N/A
Recruiting NCT05730114 - Monitoring Antiplatelet Drugs in Cardiac Arrest Patients
Completed NCT03182946 - Correcting Platelet Dysfunction After Traumatic Brain Injury
Completed NCT05033236 - Platelets and Complement Activation in Coronary Artery Bypass Graft Surgery (CABG)
Recruiting NCT04419948 - Oleocanthal Rich Olive Oil Acute Effects on Hyperglycemia and Platelet Activation in T2DM N/A
Completed NCT04400760 - The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts. Phase 2/Phase 3
Completed NCT03458351 - RIPC and Platelet Activation on Platelet Activation During Cardiopulmonary Bypass N/A
Completed NCT02368730 - Documentation of the Efficacy of Desmopressin Within the Context of Surgical Procedures N/A
Recruiting NCT06405516 - Platelet Function After Cardiac Surgery. N/A
Not yet recruiting NCT04876573 - Pilot Study for Cyproheptadine in Hospitalized Patient for COVID-19 Phase 2
Completed NCT04734028 - PTRG-DES Consortium
Completed NCT01382134 - Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction N/A
Completed NCT03028064 - Point of Care Testing of Platelet Function in Patients With Acute Upper Gastrointestinal Bleeding
Completed NCT05237492 - The Influence of Tramadol on Platelet Function Phase 4
Completed NCT01957345 - Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of Platelets N/A