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18F-choline PET-CT and MRI of Carotid Plaques — ParisK  

Plaque, Atherosclerotic Clinical Trial

Official title:
Plaque at Risk (ParisK): Molecular Imaging of Plaque Vulnerability Using 18F-choline PET-CT and MRI in Patients With Carotid Artery Atherosclerosis

Clinical Trial Summary

Accumulating data in the literature suggests that radiolabeled-choline (18F-choline) is a sensitive molecular tracer for PET-CT imaging that is taken up in activated cells and, as such, is able to identify active inflammatory sites.

Clinical Trial Description

Accumulation and subsequent activation of inflammatory cells in the atherosclerotic plaques play an essential role in transforming a stable plaque into a vulnerable plaque at risk to rupture. On this basis, the study aims to evaluate the diagnostic performance of 18F-choline PET-CT in identifying ongoing inflammation within atherosclerotic plaques. We hypothesize that 18F-choline is efficient in detecting intraplaque inflammation. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01899014
Study type Interventional
Source Maastricht University Medical Center
Contact
Status Active, not recruiting
Phase Phase 3
Start date July 2013
Completion date December 2015
View Details
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