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Placental Transfusion clinical trials

View clinical trials related to Placental Transfusion.

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NCT ID: NCT04898868 Completed - Pregnancy Related Clinical Trials

Association Between Blood Volume, the Interval From Delivery to Cord Clamping, and Number of Umbilical Cord Milking

Start date: May 19, 2021
Phase: N/A
Study type: Interventional

Delayed umbilical cord clamping (DCC), usually 1-3 minutes, is reported to be beneficial for term and preterm infants. Nevertheless, there are reasons that urge us to reevaluate the effect of DCC. First, most prior studies were conducted on American and European women. The benefits of DCC in the infants born to Asian women is not clear. Second, neonates born to Asian mothers usually have lower birth weights and placental weights compared to the neonates and placentas of American and European women. The optimal duration of DCC in Asian women remains undetermined. The objective of this study is to determine the association between the blood volume collected and the interval from delivery to cord clamping and number of umbilical cord milking in women with normal term pregnancies with vaginal delivery or elective cesarean delivery (CS). Results form this study will help us determine the optimal duration of DCC or numbers of cord milking in our population in the following studies.

NCT ID: NCT04351997 Completed - Clinical trials for Placental Transfusion

Delayed Cord Clamping in Infants Born by 'Two-step' Vaginal Delivery

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

The investigators conducted a RCT (parallel group study with 1:1 randomisation) comparing ECC (at 60 seconds) and DCC (at 180 seconds) in 90 cases of normal birth by' two-step' delivery. In term infants born by' two-step' delivery, DCC results is a higher blood volume in the newborn and facilitates the maternal-placental-fetal exchange of circulating compounds, without potentially detrimental neonatal outcomes.

NCT ID: NCT03983902 Not yet recruiting - Stem Cells Clinical Trials

Placental Transfusion Methods and Stem Cells

Start date: July 1, 2019
Phase: N/A
Study type: Interventional

To measure the levels of endothelial progenitor cells and CD34+ hematopoietic stem cells levels, and placental residual volume by delayed cord clamping, umbilical cord milking or immediate cord clamping in newborns at different gestational weeks.

NCT ID: NCT03916159 Completed - Anemia Clinical Trials

Extrauterine Placental Transfusion In Neonatal Resuscitation Of Very Low Birth Weight Infants

EXPLAIN
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

To investigate the effect of extrauterine placental transfusion (EPT) compared to delayed cord clamping (DCC) on the mean hematokrit on the first day of life in very low birth weight infants (VLBW) born by caesarian section. The investigators hypothesize that EPT provides higher blood volume during neonatal transition and improves neonatal outcome of VLBW infants.

NCT ID: NCT03731546 Completed - Preterm Infant Clinical Trials

Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

To investigate the effect of delayed cord clamping (DCC) on hematopoietic progenitor cells (HPCs), hematological parameters including haemoglobin concentration and hematocrit value in premature infants (34 weeks gestational age or less) with placental insufficiency.We hypothesized that preterm infants with placental insufficiency underwent DDC could have better hematologic parameters and hematopoietic progenitor cells compared to immediate cord clamping.

NCT ID: NCT03668782 Not yet recruiting - Clinical trials for Placental Transfusion

Cord Milking in Elective Cesarean Section

Start date: October 1, 2018
Phase:
Study type: Observational

The objective of the study was to investigate the efficacy and safety of umbilical cord milking as compared with immediate cord clamping on placental transfusion, estimated by Δ hematocrit between cord blood at birth and capillary heel hematocrit at 48 hours of age, in elective cesarean delivered neonates.

NCT ID: NCT02827409 Completed - Clinical trials for Placental Transfusion

Short-Delay Cord Clamping Compared to Extended- Delay Cord Clamping in Term Neonates That Require Resuscitation.

Term-NRIC
Start date: July 2016
Phase: N/A
Study type: Interventional

To determine whether performing extended delayed cord clamping in term neonates that require resuscitation improves early transition as compared to short-delayed cord clamping.

NCT ID: NCT02671305 Completed - Clinical trials for Placental Transfusion

Delivery Room Assistance With the Placental Circulation Intact

PCI-T
Start date: April 9, 2016
Phase: N/A
Study type: Interventional

Preterm newborns receiving placental transfusion at birth (a volume of blood coming from the placenta towards the newborn till the cord is left unclamped) have better neonatal outcomes (in particular reduction of intraventricular hemorrhage all grade). The placental transfusion strategies performed in preterm babies at delivery have been delayed cord clamping and cord milking. Both experimental strategies do not explore the contribution of the start of breathing on placental transfusion, as performed in a small time frame (30-60 seconds for delayed clamping and less than 20 sec for cord milking). To assist the newborn bedside near to the delivering mother, leaving the cord unclamped, would allow to explore the contribution of breathing,both spontaneously started or assisted by initial steps in stabilization, on early postnatal adaptation. The purpose of the present study is to assess the feasibility and effectiveness of delivery room assistance with the placental circulation intact in comparison to cord milking for improving outcomes in very preterm newborns.

NCT ID: NCT02618499 Terminated - Clinical trials for Placental Transfusion

Delayed Cord Clamping and Use of Oxytocin

Start date: May 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if oxytocin administration immediately after delivery of the infant modifies the volume of placental transfusion in healthy term infants.

NCT ID: NCT02478684 Completed - Clinical trials for Infant, Very Low Birth Weight

Delayed Cord Clamping in Preterm Neonates

DCC
Start date: July 2015
Phase: N/A
Study type: Interventional

Delayed cord clamping (DCC) from 30 to 60 seconds allows blood to continue to flow from the placenta through the umbilical cord to the infant, thus resulting in a placental transfusion. This transfusion may improve circulating volume at birth leading to a smoother postnatal transition and overall improved outcome for preterm infants. The average blood volume delivered with DCC up to 90 seconds in preterm infants has been estimated to be about 12 ml per kg with vaginal deliveries resulting in slightly higher transfusions compared to cesarean deliveries. Several several short-term benefits have been described including a reduction in the need for blood transfusions as well as a possible reduction in intraventricular hemorrhage and necrotizing enterocolitis. All mothers with threatened preterm delivery between 28 and 34 6/7 weeks will be approached for the study. Following consent, the infant will be randomly assigned to either a 30 or 60 second delay in cord clamping in the delivery room. If the infant is not breathing by 30 seconds, the cord will be clamped and the infant moved to a resuscitation area. The primary outcome is a 3 percent difference in the hematocrit at one hour (routinely obtained on all babies). With approximately 75 neonates in each group (30 and 60 second DCC), there is 80% power to detect a difference in the mean hematocrit of 3% using a two-sample t-test with a 0.05 two-sided significance level.