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Placental Abruption clinical trials

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NCT ID: NCT04356326 Recruiting - Pre-Eclampsia Clinical Trials

Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy

CHASAP
Start date: February 15, 2021
Phase: Phase 3
Study type: Interventional

A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic hypertension.

NCT ID: NCT04168606 Completed - Placenta Diseases Clinical Trials

Study on Retroplacental Hematomas in Finistère

HEMOPLACENTA
Start date: September 23, 2019
Phase:
Study type: Observational

Cases with placental abruption will be identified by interrogation of two databases of Brest University Hospital between January 2013 and December 2018. First trimester PAPPA and bhCG levels will be recorded. PlGF levels will be measured in women with an available first trimester serum sample. Histological findings in placentas, course of pregnancies, maternal and fetal characteristics will described and compared between cases with and without placental chronic inflammation.

NCT ID: NCT03455387 Completed - Pre-Eclampsia Clinical Trials

Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy.

PRECOPE
Start date: January 10, 2017
Phase:
Study type: Observational

The pre-eclampsia is a frequent pathology, concerning approximately 5 % of the pregnancies.The pre-eclampsia can evolve into severe maternal and\or foetal complications and is a major cause of mortality. The purpose of the study will to estimate the relevance of the serum markers sFlt1 and PlGF to predict the arisen of severe complications at these patients, what would allow to decrease the materno-fœtale morbi-mortality due to the pathology.

NCT ID: NCT00573118 Active, not recruiting - Preeclampsia Clinical Trials

Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity

Start date: January 2000
Phase: N/A
Study type: Observational

Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia. We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.