Placenta Previa Clinical Trial
Official title:
The Rate and Predictors of Vaginal Bleeding Among Women With Placenta Previa: A Cross-sectional Study
Placenta previa is usually diagnosed when the placenta implanted in the lower uterine segment, thus partially or totally overlying the internal os . It occurs with an incidence of 0.3-0.5%. It is associated mainly with prior caesarean delivery . The condition is frequently complicated by invasion of placental villi beyond the decidua basalis causing placenta accreta . Placenta previa is a major cause of massive haemorrhage during pregnancy and after delivery . The antepartum bleeding from placenta previa- can be life-threatening, thus, the prediction of this bleeding is of great importance . It is important to distinguish between women at high and low risk for antepartum haemorrhage with placenta previa especially at late pregnancy . However, the potential risk factors for antepartum haemorrhage in women with placenta previa have not been thoroughly examined.
Status | Not yet recruiting |
Enrollment | 250 |
Est. completion date | January 2025 |
Est. primary completion date | December 2024 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Pregnant women = 28 weeks. - Diagnosed to have placenta previa by ultrasound Exclusion Criteria: - Women with complicated pregnancies (e.g. preeclampsia, diabetes mellitus and cardiac, renal, antiphospholipid syndrome). - Women with premature rupture of membrane. - Women who will refuse to participate. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Dashe JS. Toward consistent terminology of placental location. Semin Perinatol. 2013 Oct;37(5):375-9. doi: 10.1053/j.semperi.2013.06.017. — View Citation
Love CD, Fernando KJ, Sargent L, Hughes RG. Major placenta praevia should not preclude out-patient management. Eur J Obstet Gynecol Reprod Biol. 2004 Nov 10;117(1):24-9. doi: 10.1016/j.ejogrb.2003.10.039. — View Citation
Nagase Y, Matsuzaki S, Endo M, Hara T, Okada A, Mimura K, Hiramatsu K, Kakigano A, Nakatsuka E, Miyake T, Takiuchi T, Ueda Y, Tomimatsu T, Kimura T. Placenta previa with posterior extrauterine adhesion: clinical features and management practice. BMC Surg. 2021 Jan 6;21(1):10. doi: 10.1186/s12893-020-01027-9. — View Citation
Shaamash AH, Ali MK, Attyia KM. Intramuscular 17alpha-hydroxyprogesterone caproate to decrease preterm delivery in women with placenta praevia: a randomised controlled trial. J Obstet Gynaecol. 2020 Jul;40(5):633-638. doi: 10.1080/01443615.2019.1645099. Epub 2019 Oct 31. — View Citation
Shazly SA, Badee AY, Ali MK. The use of multiple 8 compression suturing as a novel procedure to preserve fertility in patients with placenta accreta: case series. Aust N Z J Obstet Gynaecol. 2012 Aug;52(4):395-9. doi: 10.1111/j.1479-828X.2012.01449.x. Epub 2012 Jun 9. — View Citation
Wu S, Kocherginsky M, Hibbard JU. Abnormal placentation: twenty-year analysis. Am J Obstet Gynecol. 2005 May;192(5):1458-61. doi: 10.1016/j.ajog.2004.12.074. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The rate of vaginal bleeding in women presented by placenta previa at third trimester of pregnancy. | The rate of vaginal bleeding in women presented by placenta previa at third trimester of pregnancy. | Through study completion, an average of 1 and half year | |
Secondary | Identification of the potential clinical and ultrasonographic predictors of antepartum hemorrhage in women with placenta previa at third trimester of pregnancy | The result that the investigators will get from the study will help identify predictors of antepartum hemorrhage in pregnant women with placenta previa and hence preventing it, antepartum hemorrhage is a major life threatening complication of the disease wether to the baby or the mother | through study completion, an average of 1 and half year |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04518150 -
Combined Bilateral Uterine Artery Ligation and Bakri Balloon During Cesarean Section
|
N/A | |
Recruiting |
NCT04518163 -
Bakri Balloon Plus Tranexamic Acid During Cesarean Delivery for Placenta Previa
|
N/A | |
Recruiting |
NCT03638024 -
Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .
|
||
Terminated |
NCT01996345 -
Vaginal Pessary Versus Expectant Management for Placenta Previa
|
N/A | |
Recruiting |
NCT04609527 -
Management of Placenta Accreta Spectrum
|
Phase 2/Phase 3 | |
Completed |
NCT03431116 -
Low Implanted Second Trimester Placenta and Placenta Previa
|
N/A | |
Completed |
NCT03321435 -
The Placenta Previa and Fetal Weight
|
N/A | |
Enrolling by invitation |
NCT05529381 -
Anxiety and Depressive Symptoms in Placenta Previa / Accreta
|
||
Completed |
NCT04264234 -
Management Of Placenta Previa Cases And Determination Of Hospitalization Criteria
|
N/A | |
Completed |
NCT05340205 -
Blood Loss During Cesarean Delivery in Placenta Previa Patients
|
Phase 4 | |
Completed |
NCT03570723 -
Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa
|
N/A | |
Completed |
NCT05283122 -
Mostafa Maged Technique to Control and Prevent the Post-Partum Bleeding From the Lower Uterine Segment in Placenta Previa Cases
|
N/A | |
Withdrawn |
NCT01442207 -
Cerclage for Prevention on Preterm Birth in Women With Placenta Previa
|
Phase 3 | |
Not yet recruiting |
NCT03451136 -
Cervical Length in Cases of Placenta Previa
|
N/A | |
Completed |
NCT02966197 -
Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta
|
N/A | |
Recruiting |
NCT02590484 -
The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta
|
N/A | |
Recruiting |
NCT05802251 -
Sonographic Parameters and Risk of Antepartum Hemorrhage in Asymptomatic Women With Placenta Previa: A Cohort Study
|
||
Completed |
NCT03542552 -
Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa
|
Phase 3 | |
Recruiting |
NCT03124472 -
Effect of Uterine Artery Ligation Prior to Uterine Incision in Women With Placenta Previa
|
N/A | |
Recruiting |
NCT03633175 -
Progesterone in Patients With Placenta Previa
|
Phase 2 |