Plasma Concentration of Biological Markers in Placenta Accreta Spectrum

Status Terminated

Clinical Trial Summary

The purpose of this exploratory study is to determine how well maternal serum biomarkers and placental micro-particles (MP) correlate with placenta accreta spectrum (PAS) at the time of cesarean delivery in women with suspected PAS compared to women without PAS. Our aim is to determine if women with PAS have a unique MP and protein signature at the time of delivery compared with women without PAS.

Clinical Trial Description

Maternal blood samples will be taken at various points during the intrapartum period. A healthy group of women admitted for delivery will act as a matched control and will have their blood sampled at similar time points. The primary outcome variables will include the total number of micro-particles, the number of micro-particles from each cell line (platelet, placental, endothelial etc.), and protein markers The knowledge gained from this study has the potential to develop a diagnostic test for PAS with the ability to improve management and outcomes for mother and baby through earlier diagnosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04525534
Study type	Observational
Source	University of Arkansas
Contact
Status	Terminated
Phase
Start date	August 30, 2020
Completion date	July 10, 2023

View Details

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