Placenta Accreta Clinical Trial
Official title:
Plasma Concentration of Biological Markers in Placenta Spectrum
NCT number | NCT04525534 |
Other study ID # | 261299 |
Secondary ID | |
Status | Terminated |
Phase | |
First received | |
Last updated | |
Start date | August 30, 2020 |
Est. completion date | July 10, 2023 |
Verified date | November 2023 |
Source | University of Arkansas |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this exploratory study is to determine how well maternal serum biomarkers and placental micro-particles (MP) correlate with placenta accreta spectrum (PAS) at the time of cesarean delivery in women with suspected PAS compared to women without PAS. Our aim is to determine if women with PAS have a unique MP and protein signature at the time of delivery compared with women without PAS.
Status | Terminated |
Enrollment | 19 |
Est. completion date | July 10, 2023 |
Est. primary completion date | July 10, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Age 18 - to 45-years old, inclusive - Suspected or confirmed PAS or phenotypically matched controls - Delivery by cesarean section - Gestational age greater than 28 weeks - Singleton pregnancy Exclusion Criteria: - Intrauterine fetal demise, - Severe fetal anomalies (infant not expected to survive) - Emergent cesarean delivery |
Country | Name | City | State |
---|---|---|---|
United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
Lead Sponsor | Collaborator |
---|---|
University of Arkansas |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determine the level of placental-derived MPs (Microparticles/mL) | Determine quantitatively the level of placental-derived MPs which may be altered in 10 subjects with PAS and 10 phenotypically-matched controls. | Up to 6 hours | |
Primary | Identify biomarkers (picogram/mL) | Determine quantitatively the level of biomarkers which may be altered in 10 subjects with PAS and 10 phenotypically-matched controls. | Up to 6 hours | |
Secondary | Is there a correlation between maternal serum total placental MPs and biomarkers to the International Federation of Gynecology and Obstetrics (FIGO) classification for PAS at the time of cesarean delivery. | Examine the correlation between maternal serum total placental MPs and biomarkers to the FIGO classification | Up to 6 hours |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04579172 -
Conservative Management of Morbidly Adherent Anterior Situated Placenta
|
N/A | |
Completed |
NCT04593303 -
Internal Iliac Artery Ligation During Management of Placenta Accreta Spectrum
|
N/A | |
Recruiting |
NCT03638024 -
Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .
|
||
Not yet recruiting |
NCT06100640 -
Paracervical Pouch in Placenta Accreta Spectrum
|
||
Completed |
NCT05979181 -
Peripartum Cesarean Hysterectomy for Placenta Percreta
|
||
Recruiting |
NCT04609527 -
Management of Placenta Accreta Spectrum
|
Phase 2/Phase 3 | |
Recruiting |
NCT06185894 -
Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery
|
N/A | |
Completed |
NCT04573452 -
Galectin-3 and Placenta Accreta
|
||
Not yet recruiting |
NCT03273569 -
PDIUC Protocol for Placental Accreta
|
N/A | |
Completed |
NCT03707132 -
Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
|
||
Not yet recruiting |
NCT05104177 -
Effectivness of Conservative Techniques in Management of PAS
|
||
Completed |
NCT02806024 -
Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study
|
Phase 4 | |
Active, not recruiting |
NCT02784886 -
Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta
|
N/A | |
Recruiting |
NCT05070689 -
Placenta Accreta Spectrum Disorders: A. Chohan Continuous Squeezing Suture (ACCSS)
|
N/A | |
Completed |
NCT05813743 -
Detection of Urinary Bladder Wall Involvement in Abnormally Invasive Placenta (AIP) by 3D Ultrasonography
|
N/A | |
Withdrawn |
NCT04003428 -
Feasibility of HIFU for Management of Placenta Accreta (HIFU-ACCRETA)
|
N/A | |
Completed |
NCT04161521 -
Conservative Surgical Novel Technique of Placenta Accreta in Menoufia University Hospital
|
N/A | |
Recruiting |
NCT05139498 -
Conservative Management for PAS Pilot
|
N/A | |
Not yet recruiting |
NCT03530475 -
Diagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler
|
N/A | |
Recruiting |
NCT05922397 -
Placenta Accreta Spectrum Topographic Classification
|